Pharmacophore-linked pyrazolo[3,4-d]pyrimidines as EGFR-TK inhibitors: Synthesis, anticancer evaluation, pharmacokinetics, and in silico mechanistic studies.

Gaber, Ahmed A; El-Morsy, Ahmed M; Sherbiny, Farag F; Bayoumi, Ashraf H; El-Gamal, Kamal M; El-Adl, Khaled; Al-Karmalawy, Ahmed A; Ezz Eldin, Rogy R; Saleh, Marwa A; Abulkhair, Hamada S

Gaber, Ahmed A; El-Morsy, Ahmed M; Sherbiny, Farag F; Bayoumi, Ashraf H; El-Gamal, Kamal M; El-Adl, Khaled; Al-Karmalawy, Ahmed A; Ezz Eldin, Rogy R; Saleh, Marwa A; Abulkhair, Hamada S.

Afiliación

Gaber AA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
El-Morsy AM; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
Sherbiny FF; Pharmaceutical Chemistry Department, College of Pharmacy, The Islamic University, Najaf, Iraq.
Bayoumi AH; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
El-Gamal KM; Department of Chemistry, Basic Science Center and Pharmaceutical Organic Chemistry College of Pharmaceutical Science & Drug Manufacturing, Misr University for Science and Technology (MUST), Al-Motamayez District, 6th of October City, Egypt.
El-Adl K; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
Al-Karmalawy AA; Pharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
Ezz Eldin RR; Department of Medicinal Chemistry & Drug Design, Faculty of Pharmacy, Al-Azhar University, Cairo, Nasr City, Egypt.
Saleh MA; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Heliopolis University for Sustainable Development, Cairo, Egypt.
Abulkhair HS; Pharmaceutical Chemistry Department, Faculty of Pharmacy, Horus University-Egypt, New Damietta, Egypt.

Arch Pharm (Weinheim) ; : e2100258, 2021 Aug 31.

Article en En | MEDLINE | ID: mdl-34467546

Palabras clave

EGFR; SAR; Schiff bases; antitumor; docking; pyrazolo[3,4-d]pyrimidine

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Arch Pharm (Weinheim) Año: 2021 Tipo del documento: Article País de afiliación: Egipto

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