Microwave-Assisted, One-Pot Synthesis of Doxycycline under Heterogeneous Catalysis in Water.
Antibiotics (Basel)
; 10(9)2021 Sep 08.
Article
en En
| MEDLINE
| ID: mdl-34572666
ABSTRACT
The selective synthesis of active pharmaceutical molecules is a challenging issue, particularly when attempting to make the reactions even more sustainable. The present work focuses on the microwave-assisted hydrogenolysis of oxytetracycline to selectively produce α-doxycycline. Although the combination of microwave irradiation and a heterogeneous rhodium catalyst provided good conversions, the selective synthesis of active α-doxycycline was only achieved when an oxytetracycline-cyclodextrin complex was used as the starting material, giving the desired product at 34.0% yield in a one-step reaction under very mild conditions.
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1
Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
Antibiotics (Basel)
Año:
2021
Tipo del documento:
Article
País de afiliación:
Italia