New Insights into the Biology and Diagnosis of Splenic Marginal Zone Lymphomas.
Curr Oncol
; 28(5): 3430-3447, 2021 09 06.
Article
en En
| MEDLINE
| ID: mdl-34590593
ABSTRACT
Splenic marginal zone lymphoma (SMZL) is a small B-cell lymphoma, which has been recognized as a distinct pathological entity since the WHO 2008 classification. It classically presents an indolent evolution, but a third of patients progress rapidly and require aggressive treatments, such as immuno-chemotherapy or splenectomy, with all associated side effects. In recent years, advances in the comprehension of SMZL physiopathology have multiplied, thanks to the arrival of new devices in the panel of available molecular biology techniques, allowing the discovery of new molecular findings. In the era of targeted therapies, an update of current knowledge is needed to guide future researches, such as those on epigenetic modifications or the microenvironment of these lymphomas.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Neoplasias del Bazo
/
Leucemia Linfocítica Crónica de Células B
/
Linfoma de Células B
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
Idioma:
En
Revista:
Curr Oncol
Año:
2021
Tipo del documento:
Article
País de afiliación:
Francia