[The Expression and Significance of Serum Protein ROCK2 in Patients with Chronic Graft-Versus-Host Disease].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
; 29(5): 1606-1609, 2021 Oct.
Article
en Zh
| MEDLINE
| ID: mdl-34627448
ABSTRACT
OBJECTIVE:
To investigate the expression and clinical significance of serum protein ROCK2 in patients with chronic graft-versus-host disease (cGVHD) after allogeneic hematopoietic stem cell transplantation (allo-HSCT).METHODS:
The patients were divided into cGVHD group and control group (without cGVHD). The expression levels of serum protein ROCK2 were detected by ELISA in patients with or without cGVHD after allo-HSCT.RESULTS:
The expression level of ROCK2 in serum of cGVHD patients was significantly higher than those in control group, moreover, the expression level of ROCK2 in severe cGVHD group was significant higher than that in moderate and mild cGVHD group (P<0.001). The expression level of ROCK2 was significantly decreased in the serum of cGVHD patients after treatmentï¼Pï¼0.01ï¼; the expression level of ROCK2 was significantly higher in the serum of cGVHD patients with lung as the target organï¼Pï¼0.01ï¼. The median survival time of patients with severe cGVHD were significantly shorter than that of patients with mild and moderate cGVHDï¼Pï¼0.05ï¼.CONCLUSION:
ROCK2 shows certain reference value in the evaluation of severity and prognosis of cGVHD, and may be a new target for the treatment of cGVHD.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Células Madre Hematopoyéticas
/
Enfermedad Injerto contra Huésped
Límite:
Humans
Idioma:
Zh
Revista:
Zhongguo Shi Yan Xue Ye Xue Za Zhi
Asunto de la revista:
HEMATOLOGIA
Año:
2021
Tipo del documento:
Article
País de afiliación:
China