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SLEAP SMART (Sleep Apnea Screening Using Mobile Ambulatory Recorders After TIA/Stroke): A Randomized Controlled Trial.
Boulos, Mark I; Kamra, Maneesha; Colelli, David R; Kirolos, Nardin; Gladstone, David J; Boyle, Karl; Sundaram, Arun; Hopyan, Julia J; Swartz, Richard H; Mamdani, Muhammad; Loong, Desmond; Isaranuwatchai, Wanrudee; Murray, Brian J; Thorpe, Kevin E.
Afiliación
  • Boulos MI; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (M.I.B., M.K., D.R.C., N.K., D.J.G., K.B., A.S., J.J.H., R.H.S., B.J.M.).
  • Kamra M; Department of Medicine, Division of Neurology (M.I.B., D.J.G., K.B., A.S., J.J.H., R.H.S., B.J.M.), University of Toronto, Ontario, Canada.
  • Colelli DR; Institute of Health Policy, Management and Evaluation (D.L., W.I.), University of Toronto, Ontario, Canada.
  • Kirolos N; Applied Health Research Centre & Dalla Lana School of Public Health (K.E.T.), University of Toronto, Ontario, Canada.
  • Gladstone DJ; Sleep Laboratory, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (M.I.B., B.J.M.).
  • Boyle K; Stroke Medicine, Beaumont Hospital, Dublin, Ireland (K.B.).
  • Sundaram A; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Ontario, Canada (M.M., D.L., W.I).
  • Hopyan JJ; Hurvitz Brain Sciences Research Program, Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (M.I.B., M.K., D.R.C., N.K., D.J.G., K.B., A.S., J.J.H., R.H.S., B.J.M.).
  • Swartz RH; Department of Medicine, Division of Neurology (M.I.B., D.J.G., K.B., A.S., J.J.H., R.H.S., B.J.M.), University of Toronto, Ontario, Canada.
  • Mamdani M; Institute of Health Policy, Management and Evaluation (D.L., W.I.), University of Toronto, Ontario, Canada.
  • Loong D; Applied Health Research Centre & Dalla Lana School of Public Health (K.E.T.), University of Toronto, Ontario, Canada.
  • Isaranuwatchai W; Sleep Laboratory, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada (M.I.B., B.J.M.).
  • Murray BJ; Stroke Medicine, Beaumont Hospital, Dublin, Ireland (K.B.).
  • Thorpe KE; Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Ontario, Canada (M.M., D.L., W.I).
Stroke ; 53(3): 710-718, 2022 03.
Article en En | MEDLINE | ID: mdl-34628939
BACKGROUND AND PURPOSE: Poststroke/transient ischemic attack obstructive sleep apnea (OSA) is prevalent, linked with numerous unfavorable health consequences, but remains underdiagnosed. Reasons include patient inconvenience and costs associated with use of in-laboratory polysomnography (iPSG), the current standard tool. Fortunately, home sleep apnea testing (HSAT) can accurately diagnose OSA and is potentially more convenient and cost-effective compared with iPSG. Our objective was to assess whether screening for OSA in patients with stroke/transient ischemic attack using HSAT, compared with standard of care using iPSG, increased diagnosis and treatment of OSA, improved clinical outcomes and patient experiences with sleep testing, and was a cost-effective approach. METHODS: We consecutively recruited 250 patients who had sustained a stroke/transient ischemic attack within the past 6 months. Patients were randomized (1:1) to use of (1) HSAT versus (2) iPSG. Patients completed assessments and questionnaires at baseline and 6-month follow-up appointments. Patients diagnosed with OSA were offered continuous positive airway pressure. The primary outcome was compared between study arms via an intention-to-treat analysis. RESULTS: At 6 months, 94 patients completed HSAT and 71 patients completed iPSG. A significantly greater proportion of patients in the HSAT arm were diagnosed with OSA (48.8% versus 35.2%, P=0.04) compared with the iPSG arm. Furthermore, patients assigned to HSAT, compared with iPSG, were more likely to be prescribed continuous positive airway pressure (40.0% versus 27.2%), report significantly reduced sleepiness, and a greater ability to perform daily activities. Moreover, a significantly greater proportion of patients reported a positive experience with sleep testing in the HSAT arm compared with the iPSG arm (89.4% versus 31.1%). Finally, a cost-effectiveness analysis revealed that HSAT was economically attractive for the detection of OSA compared with iPSG. CONCLUSIONS: In patients with stroke/transient ischemic attack, use of HSAT compared with iPSG increases the rate of OSA diagnosis and treatment, reduces daytime sleepiness, improves functional outcomes and experiences with sleep testing, and could be an economically attractive approach. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT02454023.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ataque Isquémico Transitorio / Polisomnografía / Apnea Obstructiva del Sueño / Accidente Cerebrovascular Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Stroke Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ataque Isquémico Transitorio / Polisomnografía / Apnea Obstructiva del Sueño / Accidente Cerebrovascular Tipo de estudio: Clinical_trials / Diagnostic_studies / Etiology_studies / Prognostic_studies / Screening_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Stroke Año: 2022 Tipo del documento: Article