Mechanistic Coupling of a Novel <i>in silico</i> Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery.

Mian, Paola; Nolan, Bridget; van den Anker, John N; van Calsteren, Kristel; Allegaert, Karel; Lakhi, Nisha; Dallmann, André

Mechanistic Coupling of a Novel in silico Cotyledon Perfusion Model and a Physiologically Based Pharmacokinetic Model to Predict Fetal Acetaminophen Pharmacokinetics at Delivery.

Mian, Paola; Nolan, Bridget; van den Anker, John N; van Calsteren, Kristel; Allegaert, Karel; Lakhi, Nisha; Dallmann, André.

Afiliación

Mian P; Department of Clinical Pharmacy, Medisch Spectrum Twente, Enschede, Netherlands.
Nolan B; Department of Obstetrics and Gynecology, Richmond University Medical Center, Staten Island, NY, United States.
van den Anker JN; Department of Obstetrics and Gynecology, New York Medical College, Valhalla, NY, United States.
van Calsteren K; Division of Clinical Pharmacology, Children's National Hospital, Washington, DC, United States.
Allegaert K; Department of Pediatric Pharmacology and Pharmacometrics, University Children's Hospital Basel, Basel, Switzerland.
Lakhi N; Department of Development and Regeneration, KU Leuven, Leuven, Belgium.
Dallmann A; Department of Gynecology and Obstetrics, UZ Gasthuisberg, Leuven, Belgium.

Front Pediatr ; 9: 733520, 2021.

Article en En | MEDLINE | ID: mdl-34631628

Palabras clave

acetaminophen; ex vivo cotyledon perfusion; maternal-fetal; physiologically-based pharmacokinetics; placental transfer; pregnancy

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Pediatr Año: 2021 Tipo del documento: Article País de afiliación: Países Bajos

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