Multi-Targeted Molecular Docking, Pharmacokinetics, and Drug-Likeness Evaluation of Okra-Derived Ligand Abscisic Acid Targeting Signaling Proteins Involved in the Development of Diabetes.

Ashraf, Syed Amir; Elkhalifa, Abd Elmoneim O; Mehmood, Khalid; Adnan, Mohd; Khan, Mushtaq Ahmad; Eltoum, Nagat Elzein; Krishnan, Anuja; Baig, Mirza Sarwar

Ashraf, Syed Amir; Elkhalifa, Abd Elmoneim O; Mehmood, Khalid; Adnan, Mohd; Khan, Mushtaq Ahmad; Eltoum, Nagat Elzein; Krishnan, Anuja; Baig, Mirza Sarwar.

Afiliación

Ashraf SA; Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail 2440, Saudi Arabia.
Elkhalifa AEO; Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail 2440, Saudi Arabia.
Mehmood K; Department of Pharmaceutics, College of Pharmacy, University of Hail, Hail 2440, Saudi Arabia.
Adnan M; Department of Biology, College of Science, University of Hail, Hail 2440, Saudi Arabia.
Khan MA; Department of Microbiology and Immunology, College of Medicine and Health Sciences, UAE University, Al Ain 15551, United Arab Emirates.
Eltoum NE; Department of Clinical Nutrition, College of Applied Medical Sciences, University of Hail, Hail 2440, Saudi Arabia.
Krishnan A; Department of Molecular Medicine, School of Interdisciplinary Sciences & Technology, Jamia Hamdard, New Delhi 110062, India.
Baig MS; Department of Molecular Medicine, School of Interdisciplinary Sciences & Technology, Jamia Hamdard, New Delhi 110062, India.

Molecules ; 26(19)2021 Oct 01.

Article en En | MEDLINE | ID: mdl-34641501

Asunto(s)

Abelmoschus/química; Ácido Abscísico/farmacología; Diabetes Mellitus/metabolismo; Hipoglucemiantes/farmacología; Proteínas/metabolismo; 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1/antagonistas & inhibidores; 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1/química; 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1/metabolismo; Ácido Abscísico/química; Ácido Abscísico/metabolismo; Ácido Abscísico/farmacocinética; Aldehído Reductasa/química; Aldehído Reductasa/metabolismo; Simulación por Computador; Inhibidores Enzimáticos/química; Inhibidores Enzimáticos/farmacología; Glucoquinasa/química; Glucoquinasa/metabolismo; Glutamina/metabolismo; Glutamina-Fructosa-6-Fosfato Transaminasa (Isomerizadora)/metabolismo; Glucógeno Sintasa Quinasa 3/química; Glucógeno Sintasa Quinasa 3/metabolismo; Humanos; Hipoglucemiantes/química; Simulación del Acoplamiento Molecular; PPAR gamma/química; PPAR gamma/metabolismo; Proteínas/química; Sirtuinas/química; Sirtuinas/metabolismo

Palabras clave

Diabetes mellitus; abscisic acid; anti-diabetic; molecular docking; nutraceuticals; okra; phytohormones

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas / Ácido Abscísico / Abelmoschus / Diabetes Mellitus / Hipoglucemiantes Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2021 Tipo del documento: Article País de afiliación: Arabia Saudita

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