Deletion of the type IV secretion system promoter <i>VirB</i> in <i>Brucella abortus</i> A19 strain attenuated the virulence of the bacteria and promotes autophagy.

Deng, Xiaoyu; He, Jinke; Wang, Yueli; Yang, Qin; Yi, Jihai; Zhang, Huan; Wang, Yong; Miao, Yuhe; Wang, Zhen; Chen, Chuangfu

Deletion of the type IV secretion system promoter VirB in Brucella abortus A19 strain attenuated the virulence of the bacteria and promotes autophagy.

Deng, Xiaoyu; He, Jinke; Wang, Yueli; Yang, Qin; Yi, Jihai; Zhang, Huan; Wang, Yong; Miao, Yuhe; Wang, Zhen; Chen, Chuangfu.

Afiliación

Deng X; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.
He J; Department of Pathology, Institutes of Basic Medicine, Xinjiang Second Medical College, Kelamayi, Xinjiang, China.
Wang Y; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.
Yang Q; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.
Yi J; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.
Zhang H; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.
Wang Y; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.
Miao Y; Sunnersw Biotechnology Co., Ltd., Nan Ping, Fu Jian, China.
Wang Z; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.
Chen C; School of Animal Science and Technology, Shihezi University, Shihezi, Xinjiang, China.

Can J Microbiol ; 68(3): 165-176, 2022 Mar.

Article en En | MEDLINE | ID: mdl-34644507

Asunto(s)

Autofagia; Vacuna contra la Brucelosis; Brucella abortus; Regiones Promotoras Genéticas; Sistemas de Secreción Tipo IV; Animales; Proteínas Bacterianas/genética; Proteínas Bacterianas/metabolismo; Brucella abortus/genética; Brucella abortus/patogenicidad; Ratones; Sistemas de Secreción Tipo IV/genética; Sistemas de Secreción Tipo IV/metabolismo; Virulencia; Factores de Virulencia/genética; Factores de Virulencia/metabolismo

Palabras clave

Brucella abortus A19; autophagie; autophagy; cytokine; virB T4SS; virulence

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Autofagia / Brucella abortus / Vacuna contra la Brucelosis / Regiones Promotoras Genéticas / Sistemas de Secreción Tipo IV Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Can J Microbiol Año: 2022 Tipo del documento: Article País de afiliación: China

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