PPAR-Gamma Activation May Inhibit the In Vivo Degeneration of Bioprosthetic Aortic and Aortic Valve Grafts under Diabetic Conditions.

Katahira, Shintaro; Sugimura, Yukiharu; Grupp, Sophia; Doepp, Robin; Selig, Jessica Isabel; Barth, Mareike; Lichtenberg, Artur; Akhyari, Payam

Katahira, Shintaro; Sugimura, Yukiharu; Grupp, Sophia; Doepp, Robin; Selig, Jessica Isabel; Barth, Mareike; Lichtenberg, Artur; Akhyari, Payam.

Afiliación

Katahira S; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Sugimura Y; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Grupp S; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Doepp R; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Selig JI; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Barth M; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Lichtenberg A; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.
Akhyari P; Department of Cardiovascular Surgery, Medical Faculty and University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, 40225 Düsseldorf, Germany.

Int J Mol Sci ; 22(20)2021 Oct 14.

Article en En | MEDLINE | ID: mdl-34681744

Asunto(s)

Aorta/efectos de los fármacos; Diabetes Mellitus Experimental/complicaciones; Prótesis Valvulares Cardíacas/efectos adversos; PPAR gamma/metabolismo; Pioglitazona/farmacología; Animales; Aorta/fisiopatología; Válvula Aórtica/patología; Estenosis de la Válvula Aórtica/etiología; Estenosis de la Válvula Aórtica/terapia; Glucemia/metabolismo; Peso Corporal; Calcinosis/etiología; Calcinosis/terapia; Diabetes Mellitus Experimental/sangre; Diabetes Mellitus Experimental/tratamiento farmacológico; Regulación de la Expresión Génica/efectos de los fármacos; Ensayo de Materiales; Ratas Wistar

Palabras clave

PPAR-gamma; allograft; bioprosthetic valve; degeneration; diabetes mellitus; pioglitazone

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Aorta / Prótesis Valvulares Cardíacas / PPAR gamma / Diabetes Mellitus Experimental / Pioglitazona Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Alemania

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