Secoiridoid dimers and their biogenetic precursors from the fruits of Cornus officinalis with potential therapeutic effects on type 2 diabetes.

Peng, Zhong-Can; He, Jun; Pan, Xue-Ge; Zhang, Jia; Wang, Yu-Ming; Ye, Xian-Sheng; Xia, Cong-Yuan; Lian, Wen-Wen; Yan, Yu; He, Xiao-Li; Zhang, Wei-Ku; Xu, Jie-Kun

Peng, Zhong-Can; He, Jun; Pan, Xue-Ge; Zhang, Jia; Wang, Yu-Ming; Ye, Xian-Sheng; Xia, Cong-Yuan; Lian, Wen-Wen; Yan, Yu; He, Xiao-Li; Zhang, Wei-Ku; Xu, Jie-Kun.

Afiliación

Peng ZC; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China; Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.
He J; Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.
Pan XG; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Zhang J; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Wang YM; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Ye XS; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China.
Xia CY; Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.
Lian WW; Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.
Yan Y; Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China.
He XL; Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, People's Republic of China.
Zhang WK; Institute of Clinical Medical Sciences & Department of Pharmacy, China-Japan Friendship Hospital, Beijing 100029, People's Republic of China. Electronic address: cpuzwk@163.com.
Xu JK; School of Life Sciences & School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 100029, People's Republic of China. Electronic address: xjkbucm@163.com.

Bioorg Chem ; 117: 105399, 2021 12.

Article en En | MEDLINE | ID: mdl-34688131

Asunto(s)

Antioxidantes/farmacología; Cornus/química; Diabetes Mellitus Tipo 2/tratamiento farmacológico; Inhibidores de Glicósido Hidrolasas/farmacología; Iridoides/farmacología; Animales; Antiinflamatorios/química; Antiinflamatorios/farmacología; Antioxidantes/química; Diabetes Mellitus Tipo 2/metabolismo; Descubrimiento de Drogas; Frutas/química; Inhibidores de Glicósido Hidrolasas/química; Humanos; Hipoglucemiantes/química; Hipoglucemiantes/farmacología; Iridoides/química; Ratones; Simulación del Acoplamiento Molecular; Extractos Vegetales/química; Extractos Vegetales/farmacología; Células RAW 264.7; alfa-Glucosidasas/metabolismo

Palabras clave

Anti-inflammatory; Antioxidant; Biosynthetic pathway; Cornus officinalis; Docking study; Secoiridoid dimers; Type 2 diabetes; α-glucosidase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cornus / Iridoides / Diabetes Mellitus Tipo 2 / Inhibidores de Glicósido Hidrolasas / Antioxidantes Límite: Animals / Humans Idioma: En Revista: Bioorg Chem Año: 2021 Tipo del documento: Article

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