LiCl attenuates impaired learning and memory of APP/PS1 mice, which in mechanism involves &#945;7 nAChRs and Wnt/ß-catenin pathway.

Xiang, Jie; Ran, Long-Yan; Zeng, Xiao-Xiao; He, Wen-Wen; Xu, Yi; Cao, Kun; Dong, Yang-Ting; Qi, Xiao-Lan; Yu, Wen-Feng; Xiao, Yan; Guan, Zhi-Zhong

LiCl attenuates impaired learning and memory of APP/PS1 mice, which in mechanism involves α7 nAChRs and Wnt/ß-catenin pathway.

Xiang, Jie; Ran, Long-Yan; Zeng, Xiao-Xiao; He, Wen-Wen; Xu, Yi; Cao, Kun; Dong, Yang-Ting; Qi, Xiao-Lan; Yu, Wen-Feng; Xiao, Yan; Guan, Zhi-Zhong.

Afiliación

Xiang J; Department of Pathology, Guizhou Medical University and the Affiliated Hospital of Guizhou Medical University, Guiyang, P.R. China.
Ran LY; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, P.R. China.
Zeng XX; Department of Pathology, Guizhou Medical University and the Affiliated Hospital of Guizhou Medical University, Guiyang, P.R. China.
He WW; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, P.R. China.
Xu Y; Department of Pathology, Guizhou Medical University and the Affiliated Hospital of Guizhou Medical University, Guiyang, P.R. China.
Cao K; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, P.R. China.
Dong YT; Department of Pathology, Guizhou Medical University and the Affiliated Hospital of Guizhou Medical University, Guiyang, P.R. China.
Qi XL; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, P.R. China.
Yu WF; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, P.R. China.
Xiao Y; Key Laboratory of Endemic and Ethnic Diseases, Ministry of Education, Guizhou Medical University, Guiyang, P.R. China.
Guan ZZ; Provincial Key Laboratory of Medical Molecular Biology, Guiyang, P.R. China.

J Cell Mol Med ; 25(22): 10698-10710, 2021 11.

Article en En | MEDLINE | ID: mdl-34708522

Asunto(s)

Aprendizaje/efectos de los fármacos; Cloruro de Litio/farmacología; Memoria/efectos de los fármacos; Vía de Señalización Wnt/efectos de los fármacos; Receptor Nicotínico de Acetilcolina alfa 7/metabolismo; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Animales; Conducta Animal; Supervivencia Celular/efectos de los fármacos; Regulación de la Expresión Génica/efectos de los fármacos; Genotipo; Glucógeno Sintasa Quinasa 3 beta/metabolismo; Ratones; Ratones Transgénicos; Fenotipo; Placa Amiloide/metabolismo; Placa Amiloide/patología; Células Piramidales/efectos de los fármacos; Células Piramidales/metabolismo; Receptor Nicotínico de Acetilcolina alfa 7/genética

Palabras clave

APP/PS1 mice; AßOs; LiCl; Wnt/ß-catenin signalling pathway; α7 nAChR

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Cloruro de Litio / Vía de Señalización Wnt / Receptor Nicotínico de Acetilcolina alfa 7 / Aprendizaje / Memoria Límite: Animals Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2021 Tipo del documento: Article

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