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Discovery of novel brain-penetrant GluN2B NMDAR antagonists via pharmacophore-merging strategy as anti-stroke therapeutic agents.
Xu, Qinlong; Hu, Mengqi; Li, Jiaming; Ma, Xiaodong; Chu, Zhaoxing; Zhu, Qihua; Zhang, Yanchun; Zhu, Panhu; Huang, Yuanzheng; He, Guangwei.
Afiliación
  • Xu Q; College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Hu M; College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
  • Li J; College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China. Electronic address: lijiaming2017@ahtcm.edu.cn.
  • Ma X; College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
  • Chu Z; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China; China Pharmaceutical University, Nanjing, 210009, China.
  • Zhu Q; China Pharmaceutical University, Nanjing, 210009, China.
  • Zhang Y; College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
  • Zhu P; College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
  • Huang Y; College of Pharmacy, Anhui University of Chinese Medicine, Hefei, 230012, China.
  • He G; Hefei Institute of Pharmaceutical Industry Co., Ltd., Hefei, 230088, China.
Eur J Med Chem ; 227: 113876, 2022 Jan 05.
Article en En | MEDLINE | ID: mdl-34710748
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzofuranos / Encéfalo / Receptores de N-Metil-D-Aspartato / Fármacos Neuroprotectores / Accidente Cerebrovascular / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: China
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Benzofuranos / Encéfalo / Receptores de N-Metil-D-Aspartato / Fármacos Neuroprotectores / Accidente Cerebrovascular / Descubrimiento de Drogas Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: China