Application of in vitro PAMPA technique and in silico computational methods for blood-brain barrier permeability prediction of novel CNS drug candidates.

Radan, Milica; Djikic, Teodora; Obradovic, Darija; Nikolic, Katarina

Radan, Milica; Djikic, Teodora; Obradovic, Darija; Nikolic, Katarina.

Afiliación

Radan M; University of Belgrade - Faculty of Pharmacy, Department of Pharmaceutical, Chemistry, Vojvode Stepe 450, 11000 Belgrade, Serbia.
Djikic T; University of Belgrade - Faculty of Pharmacy, Department of Pharmaceutical, Chemistry, Vojvode Stepe 450, 11000 Belgrade, Serbia. Electronic address: tdjikic@pharmacy.bg.ac.rs.
Obradovic D; University of Belgrade - Faculty of Pharmacy, Department of Pharmaceutical, Chemistry, Vojvode Stepe 450, 11000 Belgrade, Serbia.
Nikolic K; University of Belgrade - Faculty of Pharmacy, Department of Pharmaceutical, Chemistry, Vojvode Stepe 450, 11000 Belgrade, Serbia. Electronic address: knikolic@pharmacy.bg.ac.rs.

Eur J Pharm Sci ; 168: 106056, 2022 Jan 01.

Article en En | MEDLINE | ID: mdl-34740787

Asunto(s)

Barrera Hematoencefálica; Preparaciones Farmacéuticas; Transporte Biológico; Fármacos del Sistema Nervioso Central; Humanos; Permeabilidad

Palabras clave

Blood-brain barrier permeability; CNS drugs; PAMPA; QSPR; SMD; hDAT

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Preparaciones Farmacéuticas / Barrera Hematoencefálica Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2022 Tipo del documento: Article

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