Secondary Metabolites from the Fresh Leaves of Pinus yunnanensis Franch.
Chem Biodivers
; 19(1): e202100707, 2022 Jan.
Article
en En
| MEDLINE
| ID: mdl-34741384
ABSTRACT
Fifteen metabolites, including two flavonols (1-2), three lignans (3-5), and ten diterpenoids (6-15), were isolated from the leaves of Pinus yunnanensis. Among them, flavanonol (1) were identified as undescribed flavonol derivative with natural rarely B-ring fission lactone. Massive spectroscopic methods, the DP4+ probabilities and CD/ECD calculations were applied to establish the structure of component 1. Among these compounds, taxifolin (2) showed potent cytotoxicity, having IC50 values from 21.33 to 45.48â
µg/mL, it also showed broad antibacterial activity against human pathogens with MIC values from 32 to 64â
µg/mL.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Pinus
/
Antibacterianos
Idioma:
En
Revista:
Chem Biodivers
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2022
Tipo del documento:
Article