α-Selective C(sp3)-H Thio/Selenocyanation of Ketones with Elemental Chalcogen.
J Org Chem
; 86(23): 17294-17306, 2021 Dec 03.
Article
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| MEDLINE
| ID: mdl-34784197
ABSTRACT
A facile method is disclosed for the synthesis of α-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Idioma:
En
Revista:
J Org Chem
Año:
2021
Tipo del documento:
Article