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Immunomodulation with ß-glucan from Pleurotus ostreatus in patients with endocrine-dependent breast cancer.
Spacek, Jan; Vocka, Michal; Zavadova, Eva; Konopasek, Bohuslav; Petruzelka, Lubos.
Afiliación
  • Spacek J; Department of Oncology, First Faculty of Medicine, Charles University & General University Hospital in Prague, U Nemocnice 2, Praha 2, 128 08, Czech Republic.
  • Vocka M; Department of Oncology, First Faculty of Medicine, Charles University & General University Hospital in Prague, U Nemocnice 2, Praha 2, 128 08, Czech Republic.
  • Zavadova E; Department of Oncology, First Faculty of Medicine, Charles University & General University Hospital in Prague, U Nemocnice 2, Praha 2, 128 08, Czech Republic.
  • Konopasek B; Department of Oncology, First Faculty of Medicine, Charles University & General University Hospital in Prague, U Nemocnice 2, Praha 2, 128 08, Czech Republic.
  • Petruzelka L; Department of Oncology, First Faculty of Medicine, Charles University & General University Hospital in Prague, U Nemocnice 2, Praha 2, 128 08, Czech Republic.
Immunotherapy ; 14(1): 31-40, 2022 01.
Article en En | MEDLINE | ID: mdl-34784798
ABSTRACT

Aim:

To evaluate the effect of pleuran (ß-glucan from Pleurotus ostreatus) administration on the immune profile of patients with endocrine-dependent breast cancer (clinical stages I-II) in clinical and imaging remission.

Methodology:

Antitumor cellular immunity (CD19+, CD3+, CD4+ and CD8+ T lymphocytes and natural killer cells) of 195 patients (49 in the pleuran group and 146 in the control group) was measured by flow cytometry.

Results:

We observed a significant increase in the absolute number of CD3+, CD19+, CD4+ and CD8+ T lymphocytes in the pleuran group compared with the control group.

Conclusion:

Our results suggest potential benefit of continuous pleuran administration on immune rehabilitation of cellular antitumor immunity and better prognosis in breast cancer patients in remission.
Lay abstract We aimed to evaluate the effect of pleuran (ß-glucan from oyster mushroom) on the selected immune parameters of patients with breast cancer in remission. We studied antitumor cellular immune parameters of 195 patients (49 in the pleuran group and 146 in the control group) by means of flow cytometry. After 12 months, we measured a significant increase of cytotoxic T lymphocytes in the pleuran group compared with a significant decrease in the control group. Our results suggest potential benefit of long-term administration of pleuran on antitumor cellular immunity and better prognosis in breast cancer patients in remission.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Pleurotus / Beta-Glucanos / Inmunomodulación Límite: Female / Humans / Middle aged Idioma: En Revista: Immunotherapy Asunto de la revista: ALERGIA E IMUNOLOGIA / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: República Checa

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Pleurotus / Beta-Glucanos / Inmunomodulación Límite: Female / Humans / Middle aged Idioma: En Revista: Immunotherapy Asunto de la revista: ALERGIA E IMUNOLOGIA / TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: República Checa