Linking transcription to energy: the path to understand kidney injury.
Kidney Int
; 100(6): 1165-1167, 2021 12.
Article
en En
| MEDLINE
| ID: mdl-34802556
ABSTRACT
The metabolic impairment of kidney tubular cells is a key mechanism underlying the pathophysiology of renal fibrosis. In particular, a drastic reduction in fatty acid oxidation is essentially responsible for the global energy failure occurring in the tubulointerstitial compartment. Piret et al. propose a novel transcriptional regulatory mechanism involving the decrease in the expression of Krüppel-like factor 15 in proximal tubular cells after kidney injury, which results in a major derangement of fatty acid oxidation.
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Renales
/
Túbulos Renales Proximales
Límite:
Humans
Idioma:
En
Revista:
Kidney Int
Año:
2021
Tipo del documento:
Article
País de afiliación:
Alemania