Population pharmacokinetics of clonazepam in saliva and plasma: Steps towards noninvasive pharmacokinetic studies in vulnerable populations.

Kruizinga, Matthijs D; Zuiker, Rob G J A; Bergmann, Kirsten R; Egas, Annelies C; Cohen, Adam F; Santen, Gijs W E; van Esdonk, Michiel J

Kruizinga, Matthijs D; Zuiker, Rob G J A; Bergmann, Kirsten R; Egas, Annelies C; Cohen, Adam F; Santen, Gijs W E; van Esdonk, Michiel J.

Afiliación

Kruizinga MD; Centre for Human Drug Research, Leiden, the Netherlands.
Zuiker RGJA; Juliana Children's Hospital, HAGA teaching Hospital, the Hague, the Netherlands.
Bergmann KR; Leiden University Medical Centre, Leiden, the Netherlands.
Egas AC; Centre for Human Drug Research, Leiden, the Netherlands.
Cohen AF; Centre for Human Drug Research, Leiden, the Netherlands.
Santen GWE; Department of Pharmacy, University Medical Centre Utrecht, Utrecht, the Netherlands.
van Esdonk MJ; Centre for Human Drug Research, Leiden, the Netherlands.

Br J Clin Pharmacol ; 88(5): 2236-2245, 2022 05.

Article en En | MEDLINE | ID: mdl-34811788

Asunto(s)

Clonazepam; Saliva; Teorema de Bayes; Niño; Clonazepam/farmacocinética; Humanos; Plasma; Poblaciones Vulnerables

Palabras clave

clonazepam; epilepsy; noninvasive; nonmem; pharmacokinetics; plasma; population model; saliva

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Saliva / Clonazepam Tipo de estudio: Prognostic_studies Límite: Child / Humans Idioma: En Revista: Br J Clin Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos

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