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Chemogenetics as a neuromodulatory approach to treating neuropsychiatric diseases and disorders.
Song, Jingwei; Patel, Ruchit V; Sharif, Massoud; Ashokan, Anagha; Michaelides, Michael.
Afiliación
  • Song J; National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA. Electronic address: jsong64@jh.edu.
  • Patel RV; Harvard Medical School, Boston, MA 02115, USA.
  • Sharif M; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Ashokan A; Department of Neuroscience, Johns Hopkins University, Baltimore, MD 21218, USA.
  • Michaelides M; National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA; Department of Psychiatry & Behavioral Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA. Electronic address: mike.michaelides@nih.gov.
Mol Ther ; 30(3): 990-1005, 2022 03 02.
Article en En | MEDLINE | ID: mdl-34861415
Chemogenetics enables precise, non-invasive, and reversible modulation of neural activity via the activation of engineered receptors that are pharmacologically selective to endogenous or exogenous ligands. With recent advances in therapeutic gene delivery, chemogenetics is poised to support novel interventions against neuropsychiatric diseases and disorders. To evaluate its translational potential, we performed a scoping review of applications of chemogenetics that led to the reversal of molecular and behavioral deficits in studies relevant to neuropsychiatric diseases and disorders. In this review, we present these findings and discuss the potential and challenges for using chemogenetics as a precision medicine-based neuromodulation strategy.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Terapia Genética Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2022 Tipo del documento: Article
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Terapia Genética Idioma: En Revista: Mol Ther Asunto de la revista: BIOLOGIA MOLECULAR / TERAPEUTICA Año: 2022 Tipo del documento: Article