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Mapping naso-ocular symptom scores to EQ-5D-5L utility values in Japanese cedar pollinosis.
Kumanomidou, Hiroshi; Kanai, Kengo; Oka, Aiko; Haruna, Takenori; Hirata, Yuji; Makihara, Sei-Ichiro; Higaki, Takaya; Akamatsu, Maki; Okamoto, Yoshitaka; Ikeda, Shunya; Okano, Mitsuhiro.
Afiliación
  • Kumanomidou H; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan; Kumanomidou ENT Clinic, Tokyo, Japan.
  • Kanai K; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan.
  • Oka A; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan.
  • Haruna T; Department of Otorhinolaryngology-Head & Neck Surgery, Himeji St. Mary's Hospital, Himeji, Japan.
  • Hirata Y; Department of Otorhinolaryngology-Head & Neck Surgery, Kagawa Prefectural Central Hospital, Takamatsu, Japan.
  • Makihara SI; Department of Otorhinolaryngology-Head & Neck Surgery, Kagawa Rosai Hospital, Marugame, Japan.
  • Higaki T; Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
  • Akamatsu M; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan.
  • Okamoto Y; Chiba Rosai Hospital, Ichihara, Japan.
  • Ikeda S; Department of Public Health, International University of Health and Welfare School of Medicine, Narita, Japan.
  • Okano M; Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine, Narita, Japan; Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan. Electronic address: mokano
Allergol Int ; 71(2): 207-213, 2022 Apr.
Article en En | MEDLINE | ID: mdl-34872827
BACKGROUND: The total naso-ocular symptom score (TSS) is widely used as an endpoint to evaluate the severity of seasonal allergic rhinitis. However, it is not a generic preference-based measure. We sought to develop an algorithm for mapping between the TSS and health utility in Japanese cedar pollinosis (JCP). We also performed a cost-utility analysis of sublingual immunotherapy (SLIT) for JCP by using this algorithm. METHODS: Patients with JCP filled out the TSS questionnaire and EQ-5D-5L simultaneously during the pollen season in 2019 and in 2020. We estimated a direct utility mapping model by regressing responses to individual TSS questions directly onto utility. The incremental cost-effectiveness ratio (ICER) of active SLIT to a placebo was determined by examining the drug expense and the estimated quality-adjusted life year (QALY) using a dataset from a double-blind placebo-controlled clinical trial. RESULTS: A total of 238 records were included for analysis. The estimated utility decreased with increasing severity of rhinitis. Patients with comorbid asthma showed lower utility. A negative and significant correlation was seen between the TSS and utility in both 2019 and 2020. The estimated equations were: Y(utility) = -0.0161∗X(TSS) + 1.005 in non-asthmatic JCP patients. The ICER of active SLIT to the placebo was estimated to be 4,049,720 and 6,011,218 JPY/QALY in the first and second year, respectively. CONCLUSIONS: It is possible to reasonably predict utility from the total naso-ocular symptom score by using regression models. In the estimated algorithm, pre-seasonal SLIT for JCP is cost-effective.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rinitis Alérgica Estacional / Inmunoterapia Sublingual Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Allergol Int Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rinitis Alérgica Estacional / Inmunoterapia Sublingual Tipo de estudio: Clinical_trials / Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Allergol Int Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Japón