Unravelling the Association Between Amyloid-PET and Cerebrospinal Fluid Biomarkers in the Alzheimer's Disease Spectrum: Who Really Deserves an A+?
J Alzheimers Dis
; 85(3): 1009-1020, 2022.
Article
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| MEDLINE
| ID: mdl-34897084
ABSTRACT
BACKGROUND:
Association between cerebrospinal fluid (CSF)-amyloid-ß (Aß)42 and amyloid-PET measures is inconstant across the Alzheimer's disease (AD) spectrum. However, they are considered interchangeable, along with Aß42/40 ratio, for defining 'Alzheimer's Disease pathologic change' (A+).OBJECTIVE:
Herein, we further characterized the association between amyloid-PET and CSF biomarkers and tested their agreement in a cohort of AD spectrum patients.METHODS:
We included 23 patients who underwent amyloid-PET, MRI, and CSF analysis showing reduced levels of Aß42 within a 365-days interval. Thresholds used for dichotomization were Aß42â<â640âpg/mL (Aß42+); pTauâ>â61âpg/mL (pTau+); and Aß42/40â<â0.069 (ADratio+). Amyloid-PET scans were visually assessed and processed by four pipelines (SPMCL, SPMAAL, FSGM, FSWC).RESULTS:
Different pipelines gave highly inter-correlated standardized uptake value ratios (SUVRs) (rhoâ=â0.93-0.99). The most significant findings were pTau positive correlation with SPMCL SUVR (rhoâ=â0.56, pâ=â0.0063) and Aß42/40 negative correlation with SPMCL and SPMAAL SUVRs (rhoâ=â-0.56, pâ=â0.0058; rhoâ=â-0.52, pâ=â0.0117 respectively). No correlations between CSF-Aß42 and global SUVRs were observed. In subregion analysis, both pTau and Aß42/40 values significantly correlated with cingulate SUVRs from any pipeline (R2â=â0.55-0.59, pâ<â0.0083), with the strongest associations observed for the posterior/isthmus cingulate areas. However, only associations observed for Aß42/40 ratio were still significant in linear regression models. Moreover, combining pTau with Aß42 or using Aß42/40, instead of Aß42 alone, increased concordance with amyloid-PET status from 74% to 91% based on visual reads and from 78% to 96% based on Centiloids.CONCLUSION:
We confirmed that, in the AD spectrum, amyloid-PET measures show a stronger association and a better agreement with CSF-Aß42/40 and secondarily pTau rather than Aß42 levels.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Biomarcadores
/
Péptidos beta-Amiloides
/
Enfermedad de Alzheimer
/
Amiloide
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Alzheimers Dis
Asunto de la revista:
GERIATRIA
/
NEUROLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia