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Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.
Yeh, Teng-Kuang; Song, Jen-Shin; Chang, Po-Wei; Yu, Jin-Chen; Chang, Chia-Hwa; Liao, Fang-Yu; Tien, Ya-Wen; Kuppusamy, Ramajayam; Li, An-Siou; Chen, Chi-Han; Chen, Chieh-Wen; Lin, Li-Mei; Chang, Hsin-Huei; Huang, Chih-Hsiang; Yao, Jau-Ying; Wu, Mine-Hsine; Peng, Yi-Hui; Hsueh, Ching-Cheng; Hsiao, Wen-Chi; Chen, Pei-Husan; Lin, Chin-Yu; Hsieh, Su-Huei; Shih, Chuan; Hung, Ming-Shiu; Wu, Su-Ying; Kuo, Ching-Chuan; Ueng, Shau-Hua.
Afiliación
  • Yeh TK; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Song JS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Chang PW; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Yu JC; Bio-Thera Solutions Ltd., Guangzhou, 510530, PR China.
  • Chang CH; RDD lab, Inc., New Taipei City 248, Taiwan.
  • Liao FY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Tien YW; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Kuppusamy R; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Li AS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Chen CH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Chen CW; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Lin LM; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Chang HH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Huang CH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Yao JY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Wu MH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Peng YH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Hsueh CC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Hsiao WC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Chen PH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Lin CY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Hsieh SH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Shih C; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan.
  • Hung MS; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan. Electronic address: mhung@nhri.edu.tw.
  • Wu SY; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan. Electronic address: suying@nhri.edu.tw.
  • Kuo CC; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan; Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan. Electronic address: cckuo@nhri.edu.tw.
  • Ueng SH; Institute of Biotechnology and Pharmaceutical Research, National Health Research Institutes, Miaoli County, 35053, Taiwan; School of Pharmacy, College of Medicine, National Cheng Kung University, Tainan, 701, Taiwan. Electronic address: shueng@nhri.edu.tw.
Eur J Med Chem ; 229: 114043, 2022 Feb 05.
Article en En | MEDLINE | ID: mdl-34929581
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Inhibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenasa / Amidas Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Taiwán
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diseño de Fármacos / Inhibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenasa / Amidas Límite: Animals / Humans Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: Taiwán