Characterization of the PLN p.Arg14del Mutation in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes.

Badone, Beatrice; Ronchi, Carlotta; Lodola, Francesco; Knaust, Anika E; Hansen, Arne; Eschenhagen, Thomas; Zaza, Antonio

Badone, Beatrice; Ronchi, Carlotta; Lodola, Francesco; Knaust, Anika E; Hansen, Arne; Eschenhagen, Thomas; Zaza, Antonio.

Afiliación

Badone B; Laboratory of Cardiac Cellular Physiology, Department of Biotechnology and Bioscience, University of Milano-Bicocca, 20126 Milan, Italy.
Ronchi C; Laboratory of Cardiac Cellular Physiology, Department of Biotechnology and Bioscience, University of Milano-Bicocca, 20126 Milan, Italy.
Lodola F; Laboratory of Cardiac Cellular Physiology, Department of Biotechnology and Bioscience, University of Milano-Bicocca, 20126 Milan, Italy.
Knaust AE; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Hansen A; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20249 Hamburg, Germany.
Eschenhagen T; Department of Experimental Pharmacology and Toxicology, Cardiovascular Research Center, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany.
Zaza A; German Centre for Cardiovascular Research (DZHK), Partner Site Hamburg/Kiel/Lübeck, 20249 Hamburg, Germany.

Int J Mol Sci ; 22(24)2021 Dec 16.

Article en En | MEDLINE | ID: mdl-34948294

Asunto(s)

Proteínas de Unión al Calcio/genética; Células Madre Pluripotentes Inducidas/metabolismo; Mutación/genética; Miocitos Cardíacos/metabolismo; Adulto; Animales; Calcio/metabolismo; Cardiomiopatía Dilatada/genética; Cardiomiopatía Dilatada/metabolismo; Bovinos; Células Cultivadas; Retículo Endoplásmico/genética; Retículo Endoplásmico/metabolismo; Femenino; Heterocigoto; Humanos; ATPasas Transportadoras de Calcio del Retículo Sarcoplásmico/metabolismo

Palabras clave

PLN p.Arg14del; PLN-SERCA2a interaction; dilated cardiomyopathy; hiPSC-CMs; phospholamban mutations

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al Calcio / Miocitos Cardíacos / Células Madre Pluripotentes Inducidas / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Animals / Female / Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Italia

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