Engineering Enzyme-Cleavable Oligonucleotides by Automated Solid-Phase Incorporation of Cathepsin B Sensitive Dipeptide Linkers.

Jin, Cheng; Ei-Sagheer, Afaf H; Li, Siqi; Vallis, Katherine A; Tan, Weihong; Brown, Tom

Jin, Cheng; Ei-Sagheer, Afaf H; Li, Siqi; Vallis, Katherine A; Tan, Weihong; Brown, Tom.

Afiliación

Jin C; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Ei-Sagheer AH; Department of Chemistry, Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA, UK.
Li S; Department of Science and Mathematics, Suez University, Faculty of Petroleum and Mining Engineering, Suez, 43721, Egypt.
Vallis KA; Medical Research Council, Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.
Tan W; Medical Research Council, Oxford Institute for Radiation Oncology, Department of Oncology, University of Oxford, Oxford, OX3 7DQ, UK.
Brown T; The Cancer Hospital of the University of Chinese Academy of Sciences, Zhejiang Cancer Hospital), Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, 310022, China.

Angew Chem Int Ed Engl ; 61(13): e202114016, 2022 03 21.

Article en En | MEDLINE | ID: mdl-34953094

Asunto(s)

Chalcona; Inmunoconjugados; Catepsina B/metabolismo; Dipéptidos; Inmunoconjugados/química; Oligonucleótidos

Palabras clave

Cathepsin B; DNA Breakage; Dipeptide Linker; Oligonucleotide-Drug Conjugates; Solid-Phase Synthesis

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Chalcona / Inmunoconjugados Tipo de estudio: Diagnostic_studies Idioma: En Revista: Angew Chem Int Ed Engl Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido

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