Different epileptogenic activities of murine and ovine corticotropin-releasing factor.
Brain Res
; 408(1-2): 394-8, 1987 Apr 07.
Article
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| MEDLINE
| ID: mdl-3496140
ABSTRACT
The behavioral and EEG effects of rat and ovine corticotropin releasing factor (r- and o-CRF) were compared. Both peptides were injected intracerebroventricularly into rats through chronically implanted cannulae. At the doses of 0.1 and 1 microgram both peptides activated the EEG and stimulated motor activity. At the dose of 10 micrograms they produced spiking activity. However, while o-CRF-induced spiking activity was present both in the hippocampus and in the cortical leads and was associated with generalized myoclonic movements, that induced by r-CRF was confined in the hippocampus and was not accompanied by myoclonic movements. Spiking activity induced by r-CRF was suppressed by verapamil, but was not influenced by naloxone.
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Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Hormona Liberadora de Corticotropina
/
Electroencefalografía
/
Epilepsia
Límite:
Animals
Idioma:
En
Revista:
Brain Res
Año:
1987
Tipo del documento:
Article