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Crystal structures of FolM alternative dihydrofolate reductase 1 from Brucella suis and Brucella canis.
Porter, Imani; Neal, Trinity; Walker, Zion; Hayes, Dylan; Fowler, Kayla; Billups, Nyah; Rhoades, Anais; Smith, Christian; Smith, Kaelyn; Staker, Bart L; Dranow, David M; Mayclin, Stephen J; Subramanian, Sandhya; Edwards, Thomas E; Myler, Peter J; Asojo, Oluwatoyin A.
Afiliación
  • Porter I; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Neal T; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Walker Z; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Hayes D; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Fowler K; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Billups N; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Rhoades A; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Smith C; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Smith K; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
  • Staker BL; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Dranow DM; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Mayclin SJ; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Subramanian S; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Edwards TE; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Myler PJ; Seattle Structural Genomics Center for Infectious Disease (SSGCID), Seattle, Washington, USA.
  • Asojo OA; Department of Chemistry and Biochemistry, Hampton University, 100 William R. Harvey Way, Hampton, VA 23668, USA.
Acta Crystallogr F Struct Biol Commun ; 78(Pt 1): 31-38, 2022 Jan 01.
Article en En | MEDLINE | ID: mdl-34981773
Members of the bacterial genus Brucella cause brucellosis, a zoonotic disease that affects both livestock and wildlife. Brucella are category B infectious agents that can be aerosolized for biological warfare. As part of the structural genomics studies at the Seattle Structural Genomics Center for Infectious Disease (SSGCID), FolM alternative dihydrofolate reductases 1 from Brucella suis and Brucella canis were produced and their structures are reported. The enzymes share ∼95% sequence identity but have less than 33% sequence identity to other homologues with known structure. The structures are prototypical NADPH-dependent short-chain reductases that share their highest tertiary-structural similarity with protozoan pteridine reductases, which are being investigated for rational therapeutic development.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tetrahidrofolato Deshidrogenasa / Brucelosis / Brucella canis / Brucella suis Límite: Humans Idioma: En Revista: Acta Crystallogr F Struct Biol Commun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Tetrahidrofolato Deshidrogenasa / Brucelosis / Brucella canis / Brucella suis Límite: Humans Idioma: En Revista: Acta Crystallogr F Struct Biol Commun Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos