Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.

Islam, Sadequl; Sun, Yang; Gao, Yuan; Nakamura, Tomohisa; Noorani, Arshad Ali; Li, Tong; Wong, Philip C; Kimura, Noriyuki; Matsubara, Etsuro; Kasuga, Kensaku; Ikeuchi, Takeshi; Tomita, Taisuke; Zou, Kun; Michikawa, Makoto

Islam, Sadequl; Sun, Yang; Gao, Yuan; Nakamura, Tomohisa; Noorani, Arshad Ali; Li, Tong; Wong, Philip C; Kimura, Noriyuki; Matsubara, Etsuro; Kasuga, Kensaku; Ikeuchi, Takeshi; Tomita, Taisuke; Zou, Kun; Michikawa, Makoto.

Afiliación

Islam S; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Sun Y; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Gao Y; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Nakamura T; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Noorani AA; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan.
Li T; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Wong PC; The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Kimura N; Department of Neurology, Faculty of Medicine, Oita University, Oita 870-1192, Japan.
Matsubara E; Department of Neurology, Faculty of Medicine, Oita University, Oita 870-1192, Japan.
Kasuga K; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Ikeuchi T; Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata 951-8585, Japan.
Tomita T; Laboratory of Neuropathology and Neuroscience, Faculty of Pharmaceutical Sciences, University of Tokyo, Tokyo 113-0033, Japan.
Zou K; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan kunzou@med.nagoya-cu.ac.jp michi@med.nagoya-cu.ac.jp.
Michikawa M; Department of Biochemistry, Graduate School of Medical Sciences, Nagoya City University, Nagoya 467-8601, Japan kunzou@med.nagoya-cu.ac.jp michi@med.nagoya-cu.ac.jp.

J Neurosci ; 42(8): 1574-1586, 2022 02 23.

Article en En | MEDLINE | ID: mdl-34987110

Asunto(s)

Enfermedad de Alzheimer; Apolipoproteína E4; Presenilina-1; Presenilina-2; Humanos; Enfermedad de Alzheimer/genética; Enfermedad de Alzheimer/metabolismo; Péptidos beta-Amiloides/genética; Péptidos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Precursor de Proteína beta-Amiloide/metabolismo; Secretasas de la Proteína Precursora del Amiloide/genética; Secretasas de la Proteína Precursora del Amiloide/metabolismo; Apolipoproteína E4/genética; Apolipoproteína E4/metabolismo; Mutación; Presenilina-1/genética; Presenilina-1/metabolismo; Presenilina-2/genética; Presenilina-2/metabolismo

Palabras clave

apolipoprotein E; familial AD; presenilin; secretion; sporadic AD

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Apolipoproteína E4 / Presenilina-1 / Presenilina-2 / Enfermedad de Alzheimer Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Neurosci Año: 2022 Tipo del documento: Article País de afiliación: Japón

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