Prenatal and Postnatal Pharmacotherapy in Down Syndrome: The Search to Prevent or Ameliorate Neurodevelopmental and Neurodegenerative Disorders.
Annu Rev Pharmacol Toxicol
; 62: 211-233, 2022 01 06.
Article
en En
| MEDLINE
| ID: mdl-34990205
ABSTRACT
Those with Down syndrome (DS)-trisomy for chromosome 21-are routinely impacted by cognitive dysfunction and behavioral challenges in children and adults and Alzheimer's disease in older adults. No proven treatments specifically address these cognitive or behavioral changes. However, advances in the establishment of rodent models and human cell models promise to support development of such treatments. A research agenda that emphasizes the identification of overexpressed genes that contribute demonstrably to abnormalities in cognition and behavior in model systems constitutes a rational next step. Normalizing expression of such genes may usher in an era of successful treatments applicable across the life span for those with DS.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Síndrome de Down
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Enfermedades Neurodegenerativas
Límite:
Aged
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Animals
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Female
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Humans
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Pregnancy
Idioma:
En
Revista:
Annu Rev Pharmacol Toxicol
Año:
2022
Tipo del documento:
Article