BRCA2 deficiency increases sensitivity of medulloblastoma to Olaparib by inhibiting RAD51-mediated DNA damage repair system.

Yu, J; Zhang, C; Shi, W; Rui, H; Li, H

Yu, J; Zhang, C; Shi, W; Rui, H; Li, H.

Afiliación

Yu J; Department of Neurosurgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Zhang C; Department of Neurosurgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Shi W; Department of Neurosurgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Rui H; Department of Neurosurgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China.
Li H; Department of Neurosurgery, Children's Hospital of Fudan University, 399 Wanyuan Road, Shanghai, 201102, China. lihao72720@163.com.

Clin Transl Oncol ; 24(5): 919-926, 2022 May.

Article en En | MEDLINE | ID: mdl-35001340

Asunto(s)

Neoplasias Cerebelosas; Glioma; Meduloblastoma; Animales; Proteína BRCA2/genética; Línea Celular Tumoral; Neoplasias Cerebelosas/tratamiento farmacológico; Neoplasias Cerebelosas/genética; Daño del ADN; Reparación del ADN; Humanos; Meduloblastoma/tratamiento farmacológico; Meduloblastoma/genética; Ratones; Ftalazinas; Piperazinas; Recombinasa Rad51/genética; Recombinasa Rad51/metabolismo

Palabras clave

BRCA2; Homologous recombination repair; Medulloblastoma; Olaparib

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Neoplasias Cerebelosas / Glioma / Meduloblastoma Tipo de estudio: Diagnostic_studies Límite: Animals / Humans Idioma: En Revista: Clin Transl Oncol Año: 2022 Tipo del documento: Article País de afiliación: China

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