Patho-immunological mechanisms of vitiligo: the role of the innate and adaptive immunities and environmental stress factors.
Clin Exp Immunol
; 207(1): 27-43, 2022 01 28.
Article
en En
| MEDLINE
| ID: mdl-35020865
ABSTRACT
Epidermal melanocyte loss in vitiligo, triggered by stresses ranging from trauma to emotional stress, chemical exposure or metabolite imbalance, to the unknown, can stimulate oxidative stress in pigment cells, which secrete damage-associated molecular patterns that then initiate innate immune responses. Antigen presentation to melanocytes leads to stimulation of autoreactive T-cell responses, with further targeting of pigment cells. Studies show a pathogenic basis for cellular stress, innate immune responses and adaptive immunity in vitiligo. Improved understanding of the aetiological mechanisms in vitiligo has already resulted in successful use of the Jak inhibitors in vitiligo. In this review, we outline the current understanding of the pathological mechanisms in vitiligo and locate loci to which therapeutic attack might be directed.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Vitíligo
Límite:
Humans
Idioma:
En
Revista:
Clin Exp Immunol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido