AIF, apoptosis-inducing factor; AMPK, AMP-activated protein kinase; APAP, acetaminophen; ARE, antioxidant response element; ATG, autophagy-related genes; Acetaminophen hepatotoxicity; Apoptosis; Autophagy; BSO, buthionine sulfoximine; CAD, caspase-activated DNase; CYP, cytochrome P450 enzymes; DAMPs, damage-associated molecular patterns; DMSO, dimethylsulfoxide; Drug metabolism; EndoG, endonuclease G; FSP1, ferroptosis suppressing protein 1; Ferroptosis; GPX4, glutathione peroxidase 4; GSH, glutathione; GSSG, glutathione disulfide; Gclc, glutamate­cysteine ligase catalytic subunit; Gclm, glutamate­cysteine ligase modifier subunit; HMGB1, high mobility group box protein 1; HNE, 4-hydroxynonenal; Innate immunity; JNK, c-jun N-terminal kinase; KEAP1, Kelch-like ECH-associated protein 1; LAMP, lysosomal-associated membrane protein; LC3, light chain 3; LOOH, lipid hydroperoxides; LPO, lipid peroxidation; MAP kinase, mitogen activated protein kinase; MCP-1, monocyte chemoattractant protein-1; MDA, malondialdehyde; MPT, mitochondrial permeability transition; Mitochondria; MnSOD, manganese superoxide dismutase; NAC, N-acetylcysteine; NAPQI, N-acetyl-p-benzoquinone imine; NF-κB, nuclear factor κB; NQO1, NAD(P)H:quinone oxidoreductase 1; NRF2; NRF2, nuclear factor erythroid 2-related factor 2; PUFAs, polyunsaturated fatty acids; ROS, reactive oxygen species; SMAC/DIABLO, second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI; TLR, toll like receptor; TUNEL, terminal deoxynucleotidyl transferase dUTP nick end labeling; UGT, UDP-glucuronosyltransferases; mTORC1, mammalian target of rapamycin complex 1