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Sequential allogeneic transplantation and ruxolitinib maintenance for a synchronous PCM1-JAK2 positive myeloid sarcoma and acute B-lymphoblastic leukemia.
Rizzuto, Giuliana; Leoncin, Matteo; Imbergamo, Silvia; Taurino, Daniela; Mico, Maria Caterina; Tosi, Manuela; Michelato, Anna; Buklijas, Ksenija; Spinelli, Orietta; Lussana, Federico; Lessi, Federica; Pizzi, Marco; Bonaldi, Laura; Binotto, Gianni; Rambaldi, Alessandro; Gurrieri, Carmela.
Afiliación
  • Rizzuto G; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Leoncin M; Department of Oncology-Hematology Universita` degli Studi di Milano Milan Italy.
  • Imbergamo S; Hematology and Clinical Immunology Unit Universita` degli Studi di Padova Padua Italy.
  • Taurino D; Hematology and Clinical Immunology Unit Universita` degli Studi di Padova Padua Italy.
  • Mico MC; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Tosi M; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Michelato A; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Buklijas K; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Spinelli O; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Lussana F; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Lessi F; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
  • Pizzi M; Hematology and Clinical Immunology Unit Universita` degli Studi di Padova Padua Italy.
  • Bonaldi L; Department of Pathology Università degli Studi di Padova Padua Italy.
  • Binotto G; Oncological Immunology and Molecular Diagnostic Istituto Oncologico Veneto Padua Italy.
  • Rambaldi A; Hematology and Clinical Immunology Unit Universita` degli Studi di Padova Padua Italy.
  • Gurrieri C; Hematology and Bone Marrow Transplantation Unit Azienda Socio-Sanitaria Territoriale Papa Giovanni XXIII Bergamo Italy.
Clin Case Rep ; 10(1): e05212, 2022 Jan.
Article en En | MEDLINE | ID: mdl-35028141
The translocation t(8;9)(p22;p24) results in the production of a chimeric PCM1-JAK2 fusion protein leading to the constitutive activation of the Janus Kinase 2 that renders this disease potentially sensitive to ruxolitinib. Here, we report an interesting case of PCM1-JAK2 myeloproliferative neoplasm evolving in myeloid sarcoma and B precursor ALL.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Clin Case Rep Año: 2022 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Idioma: En Revista: Clin Case Rep Año: 2022 Tipo del documento: Article