Rational design and synthesis of 2-(1<i>H</i>-indazol-6-yl)-1<i>H</i>-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants.

Im, Daseul; Jun, Joonhong; Baek, Jihyun; Kim, Haejin; Kang, Dahyun; Bae, Hyunah; Cho, Hyunwook; Hah, Jung-Mi

Rational design and synthesis of 2-(1H-indazol-6-yl)-1H-benzo[d]imidazole derivatives as inhibitors targeting FMS-like tyrosine kinase 3 (FLT3) and its mutants.

Im, Daseul; Jun, Joonhong; Baek, Jihyun; Kim, Haejin; Kang, Dahyun; Bae, Hyunah; Cho, Hyunwook; Hah, Jung-Mi.

Afiliación

Im D; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Korea.
Jun J; Institute of Pharmaceutical Science and Technology, Center for Proteinopathy, Hanyang University, Ansan, Korea.
Baek J; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Korea.
Kim H; Institute of Pharmaceutical Science and Technology, Center for Proteinopathy, Hanyang University, Ansan, Korea.
Kang D; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Korea.
Bae H; Institute of Pharmaceutical Science and Technology, Center for Proteinopathy, Hanyang University, Ansan, Korea.
Cho H; Department of Pharmacy, College of Pharmacy, Hanyang University, Ansan, Korea.
Hah JM; Institute of Pharmaceutical Science and Technology, Center for Proteinopathy, Hanyang University, Ansan, Korea.

J Enzyme Inhib Med Chem ; 37(1): 472-486, 2022 Dec.

Article en En | MEDLINE | ID: mdl-35067150

Asunto(s)

Bencimidazoles/farmacología; Diseño de Fármacos; Inhibidores de Proteínas Quinasas/farmacología; Tirosina Quinasa 3 Similar a fms/antagonistas & inhibidores; Bencimidazoles/síntesis química; Bencimidazoles/química; Cristalografía por Rayos X; Relación Dosis-Respuesta a Droga; Humanos; Modelos Moleculares; Estructura Molecular; Mutación; Inhibidores de Proteínas Quinasas/síntesis química; Inhibidores de Proteínas Quinasas/química; Relación Estructura-Actividad; Tirosina Quinasa 3 Similar a fms/genética; Tirosina Quinasa 3 Similar a fms/metabolismo

Palabras clave

Benzimidazole; FLT3; FLT3-D835Y; FLT3-ITD; Indazole

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Bencimidazoles / Diseño de Fármacos / Inhibidores de Proteínas Quinasas / Tirosina Quinasa 3 Similar a fms Límite: Humans Idioma: En Revista: J Enzyme Inhib Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2022 Tipo del documento: Article

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