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Sex-specific aging in animals: Perspective and future directions.
Bronikowski, Anne M; Meisel, Richard P; Biga, Peggy R; Walters, James R; Mank, Judith E; Larschan, Erica; Wilkinson, Gerald S; Valenzuela, Nicole; Conard, Ashley Mae; de Magalhães, João Pedro; Duan, Jingyue Ellie; Elias, Amy E; Gamble, Tony; Graze, Rita M; Gribble, Kristin E; Kreiling, Jill A; Riddle, Nicole C.
Afiliación
  • Bronikowski AM; Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, Iowa, USA.
  • Meisel RP; Department of Biology and Biochemistry, University of Houston, Houston, Texas, USA.
  • Biga PR; Department of Biology, The University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Walters JR; Department of Ecology and Evolutionary Biology, The University of Kansas, Lawrence, Kansas, USA.
  • Mank JE; Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.
  • Larschan E; Department of Bioscience, University of Exeter, Penryn, UK.
  • Wilkinson GS; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.
  • Valenzuela N; Department of Biology, University of Maryland, College Park, Maryland, USA.
  • Conard AM; Department of Ecology, Evolution, and Organismal Biology, Iowa State University, Ames, Iowa, USA.
  • de Magalhães JP; Department of Computer Science, Center for Computational and Molecular Biology, Brown University, Providence, Rhode Island, USA.
  • Duan JE; Integrative Genomics of Ageing Group, Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool, UK.
  • Elias AE; Department of Animal Science, Cornell University, Ithaca, New York, USA.
  • Gamble T; Department of Molecular Biology, Cell Biology and Biochemistry, Brown University, Providence, Rhode Island, USA.
  • Graze RM; Department of Biological Sciences, Marquette University, Milwaukee, Wisconsin, USA.
  • Gribble KE; Milwaukee Public Museum, Milwaukee, Wisconsin, USA.
  • Kreiling JA; Bell Museum of Natural History, University of Minnesota, Saint Paul, Minnesota, USA.
  • Riddle NC; Department of Biological Sciences, Auburn University, Auburn, Alabama, USA.
Aging Cell ; 21(2): e13542, 2022 02.
Article en En | MEDLINE | ID: mdl-35072344
Sex differences in aging occur in many animal species, and they include sex differences in lifespan, in the onset and progression of age-associated decline, and in physiological and molecular markers of aging. Sex differences in aging vary greatly across the animal kingdom. For example, there are species with longer-lived females, species where males live longer, and species lacking sex differences in lifespan. The underlying causes of sex differences in aging remain mostly unknown. Currently, we do not understand the molecular drivers of sex differences in aging, or whether they are related to the accepted hallmarks or pillars of aging or linked to other well-characterized processes. In particular, understanding the role of sex-determination mechanisms and sex differences in aging is relatively understudied. Here, we take a comparative, interdisciplinary approach to explore various hypotheses about how sex differences in aging arise. We discuss genomic, morphological, and environmental differences between the sexes and how these relate to sex differences in aging. Finally, we present some suggestions for future research in this area and provide recommendations for promising experimental designs.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Longevidad Límite: Animals Idioma: En Revista: Aging Cell Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Envejecimiento / Longevidad Límite: Animals Idioma: En Revista: Aging Cell Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos