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Doppler Signal and Bone Erosions at the Enthesis Are Independently Associated With Ultrasound Joint Erosive Damage in Psoriatic Arthritis.
Smerilli, Gianluca; Cipolletta, Edoardo; Destro Castaniti, Giulia Maria; Di Matteo, Andrea; Di Carlo, Marco; Moscioni, Erica; Francioso, Francesca; Mirza, Riccardo Mashadi; Grassi, Walter; Filippucci, Emilio.
Afiliación
  • Smerilli G; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona; smerilli.
  • Cipolletta E; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona.
  • Destro Castaniti GM; G.M. Destro Castaniti, MD, University of Palermo, Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, Rheumatology section, "P. Giaccone" Hospital, Palermo.
  • Di Matteo A; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona.
  • Di Carlo M; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona.
  • Moscioni E; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona.
  • Francioso F; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona.
  • Mirza RM; R. Mashadi Mirza, MD, Radiology Department, A.O. Ospedali Riuniti Marche Nord, Pesaro, Italy.
  • Grassi W; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona.
  • Filippucci E; G. Smerilli, MD, E. Cipolletta, MD, A. Di Matteo, MD, PhD, M. Di Carlo, MD, E. Moscioni, MD, F. Francioso, MD, W. Grassi, MD, PhD, E. Filippucci, MD, PhD, Marche Polytechnic University, Rheumatology Unit, Department of Clinical and Molecular Sciences, "Carlo Urbani" Hospital, Jesi, Ancona.
J Rheumatol ; 50(1): 70-75, 2023 01.
Article en En | MEDLINE | ID: mdl-35105703
ABSTRACT

OBJECTIVE:

To explore the association of the Outcome Measures in Rheumatology ultrasound (US) entheseal abnormalities with the presence of US joint bone erosions in psoriatic arthritis (PsA).

METHODS:

Consecutive patients with PsA were included in this cross-sectional study. Demographic and clinical variables were collected. A bilateral US assessment was carried out at the following entheses plantar fascia, and the quadriceps, patellar (proximal and distal), and Achilles tendons. The following US entheseal abnormalities were registered hypoechogenicity, thickening, Doppler signal < 2 mm from the bony cortex, calcification/enthesophyte, and bone erosion. The presence of US joint bone erosions was investigated at the second and fifth metacarpophalangeal joints, ulnar head, and fifth metatarsophalangeal (MTP) joint, bilaterally, as well as at the level of the most inflamed joint on physical examination. Multiple linear regression analysis was performed to identify clinical and/or US variables associated with US-detected joint bone erosions.

RESULTS:

A total of 104 patients with PsA were enrolled. At least 1 joint bone erosion was found in 47 of 104 patients (45.2%). Bone erosions were most frequently detected at the fifth MTP joint level (42/208 joints [20.2 %] in 32/104 patients [30.8%]). In the multivariate model, only a power Doppler (PD) signal at the enthesis (P < 0.001, standardized ß = 0.51), bone erosions at the enthesis (P = 0.02, standardized ß = 0.20), PsA disease duration (P = 0.04, standardized ß = 0.17), and greyscale joint synovitis (P = 0.03, standardized ß = 0.42) were associated with US-detected joint bone erosions.

CONCLUSION:

PD signal and bone erosions at the enthesis represent sonographic biomarkers of a more severe subset of PsA in terms of US-detected joint erosive damage.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sinovitis / Artritis Psoriásica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Rheumatol Año: 2023 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Sinovitis / Artritis Psoriásica Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: J Rheumatol Año: 2023 Tipo del documento: Article