Involvement of Mitochondrial Mechanisms and Cyclooxygenase-2 Activation in the Effect of Desethylamiodarone on 4T1 Triple-Negative Breast Cancer Line.

Gallyas, Ferenc; Ramadan, Fadi H J; Andreidesz, Kitti; Hocsak, Eniko; Szabo, Aliz; Tapodi, Antal; Kiss, Gyongyi N; Fekete, Katalin; Bognar, Rita; Szanto, Arpad; Bognar, Zita

Gallyas, Ferenc; Ramadan, Fadi H J; Andreidesz, Kitti; Hocsak, Eniko; Szabo, Aliz; Tapodi, Antal; Kiss, Gyongyi N; Fekete, Katalin; Bognar, Rita; Szanto, Arpad; Bognar, Zita.

Afiliación

Gallyas F; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Ramadan FHJ; Szentagothai Research Centre, University of Pecs, 7624 Pecs, Hungary.
Andreidesz K; LERN-UP Nuclear-Mitochondrial Interactions Research Group, 1245 Budapest, Hungary.
Hocsak E; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Szabo A; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Tapodi A; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Kiss GN; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Fekete K; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Bognar R; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Szanto A; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.
Bognar Z; Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, 7624 Pecs, Hungary.

Int J Mol Sci ; 23(3)2022 Jan 28.

Article en En | MEDLINE | ID: mdl-35163464

Asunto(s)

Amiodarona/análogos & derivados; Antineoplásicos/farmacología; Celecoxib/farmacología; Ciclooxigenasa 2/metabolismo; Mitocondrias/metabolismo; Neoplasias de la Mama Triple Negativas/metabolismo; Amiodarona/farmacología; Animales; Línea Celular Tumoral; Movimiento Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Resistencia a Antineoplásicos/efectos de los fármacos; Sinergismo Farmacológico; Metabolismo Energético/efectos de los fármacos; Activación Enzimática/efectos de los fármacos; Regulación Enzimológica de la Expresión Génica/efectos de los fármacos; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; Células MCF-7; Potencial de la Membrana Mitocondrial/efectos de los fármacos; Ratones; Mitocondrias/efectos de los fármacos; Neoplasias de la Mama Triple Negativas/tratamiento farmacológico; Regulación hacia Arriba/efectos de los fármacos

Palabras clave

Akt pathway; Seahorse; amiodarone; apoptosis; colony formation; invasive growth; mitochondrial fragmentation; therapy resistance; ΔΨm

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ciclooxigenasa 2 / Neoplasias de la Mama Triple Negativas / Celecoxib / Amiodarona / Mitocondrias / Antineoplásicos Límite: Animals / Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Hungria

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google