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Folic Acid Supplementation in Early Pregnancy, Homocysteine Concentration, and Risk of Gestational Diabetes Mellitus.
Guo, Yanfang; Luo, Rong; Corsi, Daniel J; White, Ruth Rennicks; Smith, Graeme; Rodger, Marc; Retnakaran, Ravi; Walker, Mark; Wen, Shi Wu.
Afiliación
  • Guo Y; Better Outcomes Registry & Network Ontario, Ottawa, ON; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Heal
  • Luo R; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa
  • Corsi DJ; Better Outcomes Registry & Network Ontario, Ottawa, ON; Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Heal
  • White RR; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, ON.
  • Smith G; Department of Obstetrics and Gynecology, Queen's Perinatal Research Unit, Kingston General Hospital, Queen's University, Kingston, ON.
  • Rodger M; Department of Medicine, Division of Hematology, University of Ottawa, Ottawa, ON.
  • Retnakaran R; Division of Endocrinology and Metabolism, University of Toronto, Toronto, ON; Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, ON.
  • Walker M; Better Outcomes Registry & Network Ontario, Ottawa, ON; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epid
  • Wen SW; Department of Obstetrics, Gynecology, and Newborn Care, OMNI Research Group, University of Ottawa Faculty of Medicine, Ottawa, ON; School of Epidemiology and Public Health, University of Ottawa Faculty of Medicine, Ottawa, ON; Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa
J Obstet Gynaecol Can ; 44(2): 196-199, 2022 Feb.
Article en En | MEDLINE | ID: mdl-35181010
ABSTRACT
We used a prospective cohort of pregnant women at 12 to 20 weeks gestation between 2002 and 2008 in Ottawa and Kingston to evaluate the impact of early pregnancy folic acid supplementation on the risk of gestational diabetes mellitus. Among 7552 eligible women, 84 (1.11%) were diagnosed of gestational diabetes mellitus. Non-significant associations were observed between gestational diabetes mellitus and folate supplementation, homocysteine levels, and methylenetetrahydrofolate reductase 677 TT genotype. Although we found no significant associations between folic acid supplementation and the risk of gestational diabetes mellitus, genetic associations were not confounded by lifestyle or socioeconomic factors, which may have biased previous studies.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Gestacional Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: J Obstet Gynaecol Can Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2022 Tipo del documento: Article
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Diabetes Gestacional Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: J Obstet Gynaecol Can Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2022 Tipo del documento: Article