Effectiveness of crizotinib versus entrectinib in ROS1-positive non-small-cell lung cancer using clinical and real-world data.
Future Oncol
; 18(17): 2063-2074, 2022 Jun.
Article
en En
| MEDLINE
| ID: mdl-35232230
ABSTRACT
Aims:
To compare clinical trial results for crizotinib and entrectinib in ROS1-positive non-small-cell lung cancer and compare clinical trial data and real-world outcomes for crizotinib. Patients &methods:
We analyzed four phase I-II studies using a simulated treatment comparison (STC). A STC of clinical trial versus real-world evidence compared crizotinib clinical data to real-world outcomes.Results:
Adjusted STC found nonsignificant trends favoring crizotinib over entrectinib objective response rate, risk ratio = 1.04 (95% CI 0.85-1.28); median duration of response, mean difference = 16.11 months (95% CI -1.57- 33.69); median progression-free survival, mean difference = 3.99 months (95% CI -6.27-14.25); 12-month overall survival, risk ratio = 1.01 (95% CI 0.90-1.12). Nonsignificant differences were observed between the trial end point values and the real-world evidence for crizotinib.Conclusions:
Crizotinib and entrectinib have comparable efficacy in ROS1-positive non-small-cell lung cancer.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Carcinoma de Pulmón de Células no Pequeñas
/
Inhibidores de Proteínas Quinasas
/
Neoplasias Pulmonares
Límite:
Humans
Idioma:
En
Revista:
Future Oncol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos