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Human defensin-inspired discovery of peptidomimetic antibiotics.
Luo, Gan; Zhang, Jue; Wang, HanBin; Sun, YaQi; Cheng, BaoLi; Xu, ZhiPeng; Zhang, Yan; Li, Hui; Lu, WuYuan; Nemeth, Elizabeta; Ganz, Tomas; Fang, XiangMing.
Afiliación
  • Luo G; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Zhang J; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Wang H; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Sun Y; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Cheng B; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Xu Z; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Zhang Y; National Clinical Research Center for Child Health, Children's Hospital, School of Medicine, Zhejiang University, Hangzhou 310052, China.
  • Li H; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
  • Lu W; Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China.
  • Nemeth E; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
  • Ganz T; Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095.
  • Fang X; Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China.
Proc Natl Acad Sci U S A ; 119(10): e2117283119, 2022 03 08.
Article en En | MEDLINE | ID: mdl-35238683
ABSTRACT
SignificanceWe report the development of peptidomimetic antibiotics derived from a natural antimicrobial peptide, human α-defensin 5. By engaging multiple bacterial targets, the lead compound is efficacious in vitro and in vivo against bacteria with highly inducible antibiotic resistance, promising a useful therapeutic agent for the treatment of infections caused by antibiotic-resistant bacteria.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Defensinas / Descubrimiento de Drogas / Peptidomiméticos / Antibacterianos Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article País de afiliación: China
Texto completo
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Defensinas / Descubrimiento de Drogas / Peptidomiméticos / Antibacterianos Límite: Humans Idioma: En Revista: Proc Natl Acad Sci U S A Año: 2022 Tipo del documento: Article País de afiliación: China