Rotenone induces regionally distinct &#945;-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice.

Rocha, Savannah M; Bantle, Collin M; Aboellail, Tawfik; Chatterjee, Debotri; Smeyne, Richard J; Tjalkens, Ronald B

Rotenone induces regionally distinct α-synuclein protein aggregation and activation of glia prior to loss of dopaminergic neurons in C57Bl/6 mice.

Rocha, Savannah M; Bantle, Collin M; Aboellail, Tawfik; Chatterjee, Debotri; Smeyne, Richard J; Tjalkens, Ronald B.

Afiliación

Rocha SM; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States of America; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States of America.
Bantle CM; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States of America.
Aboellail T; Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, United States of America.
Chatterjee D; Jefferson Comprehensive Parkinson's Center, Vickie & Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.
Smeyne RJ; Jefferson Comprehensive Parkinson's Center, Vickie & Jack Farber Institute for Neuroscience, Thomas Jefferson University, Philadelphia, PA 19107, United States of America.
Tjalkens RB; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO 80523, United States of America. Electronic address: ron.tjalkens@colostate.edu.

Neurobiol Dis ; 167: 105685, 2022 06 01.

Article en En | MEDLINE | ID: mdl-35257879

Asunto(s)

Neuronas Dopaminérgicas; Rotenona; Animales; Neuronas Dopaminérgicas/metabolismo; Ratones; Ratones Endogámicos C57BL; Microglía/metabolismo; Agregado de Proteínas; Ratas; Rotenona/toxicidad; Sustancia Negra/metabolismo; alfa-Sinucleína/metabolismo

Palabras clave

Alpha-synuclein; Astrocyte; Microglia; Neurodegeneration; Parkinson's disease; Pathology; Protein aggregation; Rotenone

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Rotenona / Neuronas Dopaminérgicas Límite: Animals Idioma: En Revista: Neurobiol Dis Asunto de la revista: NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos

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