Protein-polysaccharide interactions for the fabrication of bioactive-loaded nanocarriers: Chemical conjugates and physical complexes.
Pharmacol Res
; 178: 106164, 2022 04.
Article
en En
| MEDLINE
| ID: mdl-35272044
ABSTRACT
As unique biopolymeric architectures, covalently and electrostatically protein-polysaccharide (PRO-POL) systems can be utilized for bioactive delivery by virtue of their featured structures and unique physicochemical attributes. PRO-POL systems (i. e, microscopic /nano-dimensional multipolymer particles, molecularly conjugated vehicles, hydrogels/nanogels/oleogels/emulgels, biofunctional films, multilayer emulsion-based delivery systems, particles for Pickering emulsions, and multilayer coated liposomal nanocarriers) possess a number of outstanding attributes, like biocompatibility, biodegradability, and bioavailability with low toxicity that qualify them as powerful agents for the delivery of different bioactive ingredients. To take benefits from these systems, an in-depth understanding of the chemical conjugates and physical complexes of the PRO-POL systems is crucial. In this review, we offer a comprehensive study concerning the unique properties of covalently/electrostatically PRO-POL systems and introduce emerging platforms to fabricate relevant nanocarriers for encapsulation of bioactive components along with a subsequent sustained/controlled release.
Palabras clave
Alginate (PubChem CID: 131704328); Bioactives; Carrageenan (PubChem CID: 78126884); Casein (PubChem CID: 73995022); Chitosan (PubChem CID: 71853); Curcumin (PubChem CID: 969516); Delivery systems; Electrostatic complexation; Genipin (PubChem CID: 442424); Maltodextrins (PubChem CID: 68229136); Millard conjugation; Pectin (PubChem CID: 441476); Polysaccharides; Proteins; gum Arabic (PubChem CID: 91333377); ß-carotene (PubChem CID: 5280489)
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Polisacáridos
/
Liposomas
Idioma:
En
Revista:
Pharmacol Res
Asunto de la revista:
FARMACOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Irán