Predictors of hyperkinetic seizures.
Epilepsy Behav
; 129: 108629, 2022 04.
Article
en En
| MEDLINE
| ID: mdl-35272206
ABSTRACT
OBJECTIVE:
To identify predisposing factors for hyperkinetic seizure occurrence in a representative cohort of surgically treated patients with drug-resistant focal epilepsy.METHODS:
We retrospectively recruited all seizure-free patients after epilepsy surgery with a postoperative follow-up ≥12â¯months. Patients were classified as presenting with hyperkinetic seizures if at least 2 episodes occurred during their disease history, based on clear-cut anamnestic description and/or video-EEG/stereo-EEG recordings. We performed univariable and multivariable logistic regression models to study the association between the occurrence of hyperkinetic seizures and some predictors.RESULTS:
From a pool of 1758 consecutive patients who underwent surgery from 1996 to 2017, we identified 974 seizure-free cases. Considering at least 1-year follow-up, 937 cases were included (511 males, 91 patients with hyperkinetic seizures). Variables significantly associated with an increased risk of hyperkinetic seizure occurrence were (1) presence of epilepsy with sleep-related seizures (SRE) (Pâ¯<â¯0.001); (2) histological diagnosis of type II focal cortical dysplasia (FCD) (Pâ¯<â¯0.001); (3) resection including the frontal lobe (Pâ¯=â¯0.002) (4) duration of epilepsy at surgery (Pâ¯<â¯0.001) and (5) high seizure frequency at surgery (weekly Pâ¯=â¯0.02 - daily Pâ¯=â¯0.05). A resection including the occipital lobe reduced the risk of hyperkinetic seizures (Pâ¯=â¯0.05). About 63% of patients had hyperkinetic seizure onset before 12â¯years and it was rarely reported before 5â¯years of age.SIGNIFICANCE:
Our findings underlie the role of SRE, type II FCD and frontal epileptogenic zone as predictors of hyperkinetic seizure occurrence and highlight an age-dependent effect in favoring hyperkinetic manifestations.Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Convulsiones
/
Epilepsia Refleja
Tipo de estudio:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
/
Male
Idioma:
En
Revista:
Epilepsy Behav
Asunto de la revista:
CIENCIAS DO COMPORTAMENTO
/
NEUROLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Italia