TCA cycle off, ATF4 on for metabolic homeostasis.

Mahor, Durga; Pandey, Rishikesh; Bulusu, Vinay

Mahor, Durga; Pandey, Rishikesh; Bulusu, Vinay.

Afiliación

Mahor D; Department of Biological Sciences, Indian Institute of Science Education and Research, ITI Transit Campus, Khodasingi, Berhampur-760010, Odisha, India.
Pandey R; Department of Biological Sciences, Indian Institute of Science Education and Research, ITI Transit Campus, Khodasingi, Berhampur-760010, Odisha, India.
Bulusu V; Department of Biological Sciences, Indian Institute of Science Education and Research, ITI Transit Campus, Khodasingi, Berhampur-760010, Odisha, India. Electronic address: vbulusu@iiserbpr.ac.in.

Trends Biochem Sci ; 47(7): 558-560, 2022 07.

Article en En | MEDLINE | ID: mdl-35292185

RESUMEN

Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox metabolic pathways.

Asunto(s)

Aminoácidos; Ciclo del Ácido Cítrico; Homeostasis; Redes y Vías Metabólicas; Oxidación-Reducción

Palabras clave

ATF4; TCA cycle; fumarate hydratase; glutathione synthesis; integrated stress response; succinate dehydrogenase

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Ciclo del Ácido Cítrico / Aminoácidos Idioma: En Revista: Trends Biochem Sci Año: 2022 Tipo del documento: Article País de afiliación: India

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