TCA cycle off, ATF4 on for metabolic homeostasis.
Trends Biochem Sci
; 47(7): 558-560, 2022 07.
Article
en En
| MEDLINE
| ID: mdl-35292185
Tricarboxylic acid (TCA) cycle is a major hub for catabolic and anabolic reactions, yet cellular metabolic adaptations following its inhibition are largely unknown. Using multi-tiered omics approaches, Ryan et al. have shown convergent activation of the integrated stress response (ISR) through ATF4-mediated rewiring of cellular amino acid and redox metabolic pathways.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Ciclo del Ácido Cítrico
/
Aminoácidos
Idioma:
En
Revista:
Trends Biochem Sci
Año:
2022
Tipo del documento:
Article
País de afiliación:
India