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Post-Stroke Depression and Cognitive Aging: A Multicenter, Prospective Cohort Study.
Shin, Minyoung; Sohn, Min Kyun; Lee, Jongmin; Kim, Deog Young; Shin, Yong-Il; Oh, Gyung-Jae; Lee, Yang-Soo; Joo, Min Cheol; Lee, So Young; Song, Min-Keun; Han, Junhee; Ahn, Jeonghoon; Lee, Young-Hoon; Chang, Won Hyuk; Shin, Seyoung; Choi, Soo Mi; Lee, Seon Kui; Kim, Yun-Hee.
Afiliación
  • Shin M; Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Sohn MK; Department of Counseling Psychology, Seoul Graduate School of Counseling Psychology, Seoul 03136, Korea.
  • Lee J; Department of Rehabilitation Medicine, School of Medicine, Chungnam National University, Daejeon 34134, Korea.
  • Kim DY; Department of Rehabilitation Medicine, Konkuk University School of Medicine, Seoul 05030, Korea.
  • Shin YI; Department and Research Institute of Rehabilitation Medicine, Yonsei University College of Medicine, Seoul 03722, Korea.
  • Oh GJ; Department of Rehabilitation Medicine, Pusan National University School of Medicine, Pusan National University Yangsan Hospital, Yangsan 46241, Korea.
  • Lee YS; Department of Preventive Medicine, Wonkwang University School of Medicine, Iksan 51538, Korea.
  • Joo MC; Department of Rehabilitation Medicine, Kyungpook National University School of Medicine, Kyungpook National University Hospital, Daegu 41566, Korea.
  • Lee SY; Department of Rehabilitation Medicine, Wonkwang University School of Medicine, Iksan 51538, Korea.
  • Song MK; Department of Rehabilitation Medicine, Jeju National University School of Medicine, Jeju 63243, Korea.
  • Han J; Department of Physical and Rehabilitation Medicine, Chonnam National University Medical School, Kwangju 61186, Korea.
  • Ahn J; Department of Statistics, Hallym University, Chunchon 24252, Korea.
  • Lee YH; Department of Health Convergence, Ewha Womans University, Seoul 03760, Korea.
  • Chang WH; Department of Preventive Medicine, Wonkwang University School of Medicine, Iksan 51538, Korea.
  • Shin S; Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Choi SM; Department of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, Korea.
  • Lee SK; Division of Chronic Disease Prevention, Center for Disease, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.
  • Kim YH; Division of Chronic Disease Prevention, Center for Disease, Korea Disease Control and Prevention Agency, Cheongju 28159, Korea.
J Pers Med ; 12(3)2022 Mar 03.
Article en En | MEDLINE | ID: mdl-35330389
ABSTRACT

Background:

This study investigated the impact of post-stroke depression (PSD) on cognitive aging in elderly stroke patients.

Methods:

This study was an interim analysis of the Korean Stroke Cohort for Functioning and Rehabilitation. Among 10,636 patients with first-ever stroke, a total of 3215 patients with normal cognitive function three months post-stroke were included in the analysis. PSD was defined using the Korean Geriatric Depression Scale Short Form (K-GDS-SF) at three months. Cognitive aging was defined as a decline in the Korean version of the Mini-Mental Status Examination (K-MMSE) score to less than the second percentile.

Results:

The hazard ratio (HR) of PSD for cognitive decline was 2.16 (95% CI, 1.34−3.50, p < 0.01) in the older group (age ≥65 years), and 1.02 (95% CI, 0.50−2.07, n.s.) in the younger group (age <65 years). When the older group was divided by sex, the HR was 2.50 (95% CI, 1.26−4.96, p < 0.01) in male patients and 1.80 (95% CI, 0.93−3.51, n.s.) in female patients. However, women showed a higher incidence of cognitive decline in both the PSD and no PSD groups. Among K-GDS-SF factors, "Negative judgment about the past, present, and future" increased the HR of PSD in older male patients.

Conclusions:

Early PSD increased the HR for cognitive decline in older stroke patients, mainly in males. Specifically, older male patients with negative thinking were at increased risk of cognitive decline. The findings also suggest that older women may be at risk for cognitive decline. Therefore, preventive interventions for cognitive decline should be tailored differently for men and women.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article