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Association of TLR4 Rs4986791 Polymorphism and TLR9 Haplotypes with Acute Myeloid Leukemia Susceptibility: A Case-Control Study of Adult Patients.
Banescu, Claudia; Tripon, Florin; Bojan, Anca S; Trifa, Adrian P; Muntean, Carmen; Crauciuc, George Andrei; Boglis, Alina; Candea, Marcela; Lazar, Erzsebet; Jimbu, Laura; Iancu, Mihaela.
Afiliación
  • Banescu C; Center for Advanced Medical and Pharmaceutical Research, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, 38, Gheorghe Marinescu Street, 540139 Targu Mures, Romania.
  • Tripon F; Genetics Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
  • Bojan AS; Genetics Laboratory, County Emergency Clinical Hospital of Targu Mures, 50, Gheorghe Marinescu Street, 540136 Targu Mures, Romania.
  • Trifa AP; Center for Advanced Medical and Pharmaceutical Research, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, 38, Gheorghe Marinescu Street, 540139 Targu Mures, Romania.
  • Muntean C; Genetics Department, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
  • Crauciuc GA; Department of Hematology, The Oncology Institute "Ion Chiricuta" Cluj-Napoca, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8, Victor Babes, Street, 400012 Cluj-Napoca, Romania.
  • Boglis A; Department of Medical Genetics, "Iuliu Hatieganu" University of Medicine and Pharmacy, 8, Victor Babes, Street, 400012 Cluj-Napoca, Romania.
  • Candea M; Department of Genetics, The Oncology Institute "Ion Chiricuta" Cluj-Napoca, 34-36 Republicii Street, 400015 Cluj-Napoca, Romania.
  • Lazar E; Department of Clinical Science, George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, 540139 Targu Mures, Romania.
  • Jimbu L; Center for Advanced Medical and Pharmaceutical Research, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, 38, Gheorghe Marinescu Street, 540139 Targu Mures, Romania.
  • Iancu M; Center for Advanced Medical and Pharmaceutical Research, "George Emil Palade" University of Medicine, Pharmacy, Science and Technology, 38, Gheorghe Marinescu Street, 540139 Targu Mures, Romania.
J Pers Med ; 12(3)2022 Mar 06.
Article en En | MEDLINE | ID: mdl-35330409
ABSTRACT
Toll-like receptors (TLRs) have an important role in innate immunity, and single nucleotide polymorphisms (SNPs) of TLR genes influence the risk of developing hematological malignancies. We aimed to evaluate the effect of TLR2 (rs5743708), TLR4 (rs11536889, rs4986790, rs4986791), TLR9 (rs187084, rs352140, rs5743836) on AML risk, the relation between investigated SNPs and somatic mutations, clinical features, and the overall survival of adult AML patients. All mentioned SNPs were genotyped in 511 AML cases and 503 healthy controls. DNMT3A (R882), FLT3 (D835, ITD), and NPM1 mutations' status were investigated in AML patients. TLR4 rs4986791 was associated with an increased risk of AML under the dominant model (OR = 1.61, 95% CI 1.001-2.59). Variant genotypes of the TLR4 rs4986790 or rs4986791 were associated with the odds of developing AML in the codominant model (OR = 3.14; 95% CI 1.12-8.84; p = 0.032). The TLR9 rs5743836 variant genotype was associated with the NPM1 mutation (p = 0.002). The investigated SNPs were not associated with the DNMT3A, FLT3 mutations and had no significant contribution to the hazard of death after adjusting for covariates. Our findings suggest that TLR4 rs4986791 is associated with AML susceptibility. The combined variant genotypes of TLR4 rs4986790 and rs4986791 increase AML risk, the TLR9 C-G-A haplotype may represent a promising approach to predict a person's risk for developing AML.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article País de afiliación: Rumanía

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article País de afiliación: Rumanía