Considering Organismal Physiology in Laboratory Studies of Rodent Behavior.
Annu Rev Neurosci
; 45: 387-402, 2022 07 08.
Article
en En
| MEDLINE
| ID: mdl-35395164
ABSTRACT
Any experiment conducted in a rodent laboratory is done so against the backdrop of each animal's physiological state at the time of the experiment. This physiological state can be the product of multiple factors, both internal (e.g., animal sex, strain, hormone cycles, or circadian rhythms) and external (e.g., housing conditions, social status, and light/dark phases). Each of these factors has the potential to influence experimental outcomes, either independently or via interactions with others, and yet there is little consistency across laboratories in terms of the weight with which they are considered in experimental design. Such discrepancies-both in practice and in reporting-likely contribute to the perception of a reproducibility crisis in the field of behavioral neuroscience. In this review, we discuss how several of these sources of variability can impact outcomes within the realm of common learning and memory paradigms.
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Texto completo:
1
Colección:
01-internacional
Banco de datos:
MEDLINE
Asunto principal:
Roedores
/
Laboratorios
Límite:
Animals
Idioma:
En
Revista:
Annu Rev Neurosci
Año:
2022
Tipo del documento:
Article