Salt-inducible kinase 2 (SIK2) inhibitor ARN-3236 attenuates bleomycin-induced pulmonary fibrosis in mice.

Zou, Liangneng; Hong, Dequn; Li, Kecong; Jiang, Bingyuan

Zou, Liangneng; Hong, Dequn; Li, Kecong; Jiang, Bingyuan.

Afiliación

Zou L; Department of General Medicine, The Fifth Hospital of Xiamen, 101 Min'an Road, Maxiang, Xiang'an, Xiamen, 361101, Fujian, People's Republic of China.
Hong D; Department of Emergency, The Fifth Hospital of Xiamen, 101 Min'an Road, Maxiang, Xiang'an, Xiamen, 361101, Fujian, People's Republic of China.
Li K; The Affiliated Second Hospital of Xiamen Medical College, 566 Shengguang Road, Ji'mei, Xiamen, 361000, Fujian, People's Republic of China. lkc00@163.com.
Jiang B; Critical Care Medicine, The Fifth Hospital of Xiamen, 101 Min'an Road, Maxiang, Xiang'an, Xiamen, 361101, Fujian, People's Republic of China. byjiang_fhxm@163.com.

BMC Pulm Med ; 22(1): 140, 2022 Apr 11.

Article en En | MEDLINE | ID: mdl-35410283

Asunto(s)

Bleomicina; Fibrosis Pulmonar; Animales; Bleomicina/toxicidad; Fibroblastos/metabolismo; Humanos; Pulmón/patología; Ratones; Ratones Endogámicos C57BL; Fibrosis Pulmonar/inducido químicamente; Fibrosis Pulmonar/tratamiento farmacológico; Fibrosis Pulmonar/metabolismo; ARN Interferente Pequeño/efectos adversos; ARN Interferente Pequeño/metabolismo; Factor de Crecimiento Transformador beta1/metabolismo

Palabras clave

ARN-3236; CREB-regulated transcription co-activator 2 (CRTC2); Pulmonary fibrosis; Salt-inducible kinase 2 (SIK2); cAMP response element binding protein (CREB)

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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Fibrosis Pulmonar / Bleomicina Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: BMC Pulm Med Año: 2022 Tipo del documento: Article

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