Your browser doesn't support javascript.
loading
Expression of miRNA-1-3p and its target gene in hair follicle cycle development of Liaoning Cashmere goat.
Zhang, Guishan; Xu, Jing; Zhang, Yingnan; Yang, Shubao; Jiang, Huaizhi.
Afiliación
  • Zhang G; School of Public Health, Jilin Medical University, Jilin, Jilin Province, China.
  • Xu J; School of Basic Medical Sciences, Jilin Medical University, Jilin, Jilin Province, China.
  • Zhang Y; School of Public Health, Jilin Medical University, Jilin, Jilin Province, China.
  • Yang S; School of Basic Medical Sciences, Jilin Medical University, Jilin, Jilin Province, China.
  • Jiang H; College of Animal Science and Technology, Jilin Agricultural University, Changchun, Jilin Province, China.
Anim Biotechnol ; 34(6): 1937-1942, 2023 Nov.
Article en En | MEDLINE | ID: mdl-35443150
ABSTRACT
MicroRNA exerts an important regulatory role in almost all the biological process, including hair follicle development in Liaoning Cashmere goat. In order to improve the Cashmere performance of goat, the regulatory role of microRNA in hair follicle cycle has drawn hotspot attention. However, the molecular mechanisms of miRNA-1-3p involved in hair follicle development are poorly understood. In this study, we found that miRNA-1-3p was less expressed in anagen stage of hair follicle cycle of Cashmere goat than that in telogen stage by using RT-qPCR and immunoblotting analysis, in contrast to the expression pattern of FGF14. The Dual-Luciferase reporter assay was employed to verify the relationship between miRNA-1-3p and FGF14. The results showed that miRNA-1-3p specifically binds to the 3'UTR of FGF14 mRNA, and FGF14 is the target gene of miR-1-3p. In conclusion, this study shows that miRNA-1-3p may regulate hair follicle development in Liaoning Cashmere goats by targeting FGF14.
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Folículo Piloso / MicroARNs Límite: Animals Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Folículo Piloso / MicroARNs Límite: Animals Idioma: En Revista: Anim Biotechnol Asunto de la revista: BIOTECNOLOGIA Año: 2023 Tipo del documento: Article País de afiliación: China