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Maternal obesity during pregnancy leads to derangements in one-carbon metabolism and the gut microbiota: implications for fetal development and offspring wellbeing.
Rubini, Eleonora; Schenkelaars, Nicole; Rousian, Melek; Sinclair, Kevin D; Wekema, Lieske; Faas, Marijke M; Steegers-Theunissen, Régine P M; Schoenmakers, Sam.
Afiliación
  • Rubini E; Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Schenkelaars N; Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Rousian M; Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands.
  • Sinclair KD; School of Biosciences, University of Nottingham, Nottingham, United Kingdom.
  • Wekema L; Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Faas MM; Division of Medical Biology, Department of Pathology and Medical Biology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • Steegers-Theunissen RPM; Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands. Electronic address: r.steegers@erasmusmc.nl.
  • Schoenmakers S; Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, The Netherlands.
Am J Obstet Gynecol ; 227(3): 392-400, 2022 09.
Article en En | MEDLINE | ID: mdl-35452650
ABSTRACT
A healthy diet before and during pregnancy is beneficial in acquiring essential B vitamins involved in 1-carbon metabolism, and in maintaining a healthy gut microbiota. Each play important roles in fetal development, immune-system remodeling, and pregnancy-nutrient acquisition. Evidence shows that there is a reciprocal interaction between the one-carbon metabolism and the gut microbiota given that dietary intake of B vitamins has been shown to influence the composition of the gut microbiota, and certain gut bacteria also synthesize B vitamins. This reciprocal interaction contributes to the individual's overall availability of B vitamins and, therefore, should be maintained in a healthy state during pregnancy. There is an emerging consensus that obese pregnant women often have derangements in 1-carbon metabolism and gut dysbiosis owing to high intake of nutritiously poor foods and a chronic systemic inflammatory state. For example, low folate and vitamin B12 in obese women coincide with the decreased presence of B vitamin-producing bacteria and increased presence of inflammatory-associated bacteria from approximately mid-pregnancy. These alterations are risk factors for adverse pregnancy outcomes, impaired fetal development, and disruption of fetal growth and microbiota formation, which may lead to potential long-term offspring metabolic and neurologic disorders. Therefore, preconceptional and pregnant obese women may benefit from dietary and lifestyle counseling to improve their dietary nutrient intake, and from monitoring their B vitamin levels and gut microbiome by blood tests and microbiota stool samples. In addition, there is evidence that some probiotic bacteria have folate biosynthetic capacity and could be used to treat gut dysbiosis. Thus, their use as an intervention strategy for obese women holds potential and should be further investigated. Currently, there are many knowledge gaps concerning the relationship between one-carbon metabolism and the gut microbiota, and future research should focus on intervention strategies to counteract B vitamin deficiencies and gut dysbiosis in obese pregnant women, commencing with the use of probiotic and prebiotic supplements.
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complejo Vitamínico B / Microbioma Gastrointestinal / Obesidad Materna Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos

Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Complejo Vitamínico B / Microbioma Gastrointestinal / Obesidad Materna Tipo de estudio: Risk_factors_studies Límite: Female / Humans / Pregnancy Idioma: En Revista: Am J Obstet Gynecol Año: 2022 Tipo del documento: Article País de afiliación: Países Bajos