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Insight into Targeting Exon20 Insertion Mutations of the Epidermal Growth Factor Receptor with Wild Type-Sparing Inhibitors.
Lategahn, Jonas; Tumbrink, Hannah L; Schultz-Fademrecht, Carsten; Heimsoeth, Alena; Werr, Lisa; Niggenaber, Janina; Keul, Marina; Parmaksiz, Fatma; Baumann, Matthias; Menninger, Sascha; Zent, Eldar; Landel, Ina; Weisner, Jörn; Jeyakumar, Kirujan; Heyden, Leonie; Russ, Nicole; Müller, Fabienne; Lorenz, Carina; Brägelmann, Johannes; Spille, Inga; Grabe, Tobias; Müller, Matthias P; Heuckmann, Johannes M; Klebl, Bert M; Nussbaumer, Peter; Sos, Martin L; Rauh, Daniel.
Afiliación
  • Lategahn J; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
  • Tumbrink HL; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.
  • Schultz-Fademrecht C; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
  • Heimsoeth A; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
  • Werr L; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
  • Niggenaber J; PearlRiver Bio GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
  • Keul M; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
  • Parmaksiz F; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
  • Baumann M; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
  • Menninger S; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
  • Zent E; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.
  • Landel I; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
  • Weisner J; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.
  • Jeyakumar K; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
  • Heyden L; Molecular Pathology, Institute of Pathology, University Hospital of Cologne, Kerpener Str. 62, 50937 Cologne, Germany.
  • Russ N; Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931 Cologne, Germany.
  • Müller F; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
  • Lorenz C; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
  • Brägelmann J; Lead Discovery Center GmbH, Otto-Hahn-Str. 15, 44227 Dortmund, Germany.
  • Spille I; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.
  • Grabe T; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
  • Müller MP; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.
  • Heuckmann JM; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
  • Klebl BM; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.
  • Nussbaumer P; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
  • Sos ML; Faculty of Chemistry and Chemical Biology, TU Dortmund University, Otto-Hahn-Str. 4a, 44227 Dortmund, Germany.
  • Rauh D; Drug Discovery Hub Dortmund (DDHD) am Zentrum für Integrierte Wirkstoffforschung (ZIW), 44227 Dortmund, Germany.
J Med Chem ; 65(9): 6643-6655, 2022 05 12.
Article en En | MEDLINE | ID: mdl-35486541
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Alemania
Texto completo
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Banco de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares Límite: Animals / Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Alemania